Title:
ANTIHEPATITIS C VIRUS AGENT AND ANTI-HIV AGENT
Document Type and Number:
WIPO Patent Application WO/2004/080453
Kind Code:
A1
Abstract:
An antihepatitis C virus agent or anti-HIV agent which contains as an active ingredient either a fullerene derivative having a nitrogen atom constituting a ring together with a pair of adjacent carbon atoms bonded to each other which are among the carbon atoms constituting the carbon cluster skeleton of a fullerene or a quaternary amine salt of the derivative.
Inventors:
MASHINO TADAHIKO (JP)
SHIMOTOHNO KUMIKO (JP)
SHIMOTOHNO KUMIKO (JP)
Application Number:
PCT/JP2004/003080
Publication Date:
September 23, 2004
Filing Date:
March 10, 2004
Export Citation:
Assignee:
MITSUBISHI CORP (JP)
MASHINO TADAHIKO (JP)
SHIMOTOHNO KUMIKO (JP)
MASHINO TADAHIKO (JP)
SHIMOTOHNO KUMIKO (JP)
International Classes:
A61K31/194; A61K31/403; A61K31/407; A61K31/4439; A61P1/16; A61P31/14; A61P31/18; C07D209/56; C07D209/58; C07D487/04; (IPC1-7): A61K31/403; A61K31/194; A61K31/407; A61K31/4439; A61P1/16; A61P31/14; A61P31/18; C07D209/58; C07D487/04; C07D401/04
Foreign References:
| US20030036562A1 | 2003-02-20 | |||
| JPH08503693A | 1996-04-23 | |||
| JP2000514412A | 2000-10-31 | |||
| JP2001302630A | 2001-10-31 |
Other References:
BOSI S. ET AL: "Synthesis and Anti-HIV Properties of New Water-Soluble Bis-functionalized[60]fullerene Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 24, 2003, pages 4437 - 4440, XP002979769
GHARBI N. ET AL: "Chromatographic and electrophoretic profiles of two acidic water-soluble fullerene derivatives", PROCEEDINGS - ELECTROCHEMICAL SOCIETY, vol. 2002-12, 2002, pages 443 - 450, XP002979770
GHARBI N. ET AL: "Chromatographic Separation and Identification of a Water-Soluble Dendritic Methano[60]fullerene Octadecaacid", ANALYTICAL CHEMISTRY, vol. 75, no. 16, 2003, pages 4217 - 4222, XP002979771
SCHUSTER D. ET AL: "Evaluation of the anti-HIV potency of a water-soluble dendrimeric fullerene", PROCEEDINGS - ELECTROCHEMICAL SOCIETY, vol. 2000-11, 2000, pages 267 - 270, XP002979772
HUANG Y.-L. ET AL: "Blockage of apoptotic signaling of transforming growth factor-beta in human hepatoma cells by carboxyfullerene", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 254, no. 1, 1998, pages 38 - 43, XP002979773
MASHINO T. ET AL: "Antibacterial and Antiproliferative Activity of Cationic Fullerene Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 24, 2003, pages 4395 - 4397, XP002979768
BOSI S. ET AL: "Antimycobacterial activity of ionic fullerene derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 10, 2000, pages 1043 - 1045, XP004204601
GHARBI N. ET AL: "Chromatographic and electrophoretic profiles of two acidic water-soluble fullerene derivatives", PROCEEDINGS - ELECTROCHEMICAL SOCIETY, vol. 2002-12, 2002, pages 443 - 450, XP002979770
GHARBI N. ET AL: "Chromatographic Separation and Identification of a Water-Soluble Dendritic Methano[60]fullerene Octadecaacid", ANALYTICAL CHEMISTRY, vol. 75, no. 16, 2003, pages 4217 - 4222, XP002979771
SCHUSTER D. ET AL: "Evaluation of the anti-HIV potency of a water-soluble dendrimeric fullerene", PROCEEDINGS - ELECTROCHEMICAL SOCIETY, vol. 2000-11, 2000, pages 267 - 270, XP002979772
HUANG Y.-L. ET AL: "Blockage of apoptotic signaling of transforming growth factor-beta in human hepatoma cells by carboxyfullerene", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 254, no. 1, 1998, pages 38 - 43, XP002979773
MASHINO T. ET AL: "Antibacterial and Antiproliferative Activity of Cationic Fullerene Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 24, 2003, pages 4395 - 4397, XP002979768
BOSI S. ET AL: "Antimycobacterial activity of ionic fullerene derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 10, 2000, pages 1043 - 1045, XP004204601
Attorney, Agent or Firm:
Nishizawa, Toshio (11-1 Minami-Aoyama 6-chom, Minato-ku Tokyo, JP)
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