Title:
ANTIMALARIAL
Document Type and Number:
WIPO Patent Application WO/2016/063848
Kind Code:
A1
Abstract:
Provided is an antimalarial that effectively acts against malaria caused by
Plasmodium infection, particularly chloroquine-resistant and/or artemisinin-resistant Plasmodium infection. Further provided is an antimalarial with which the efficacy of an active ingredient is effectively sustainable. The antimalarial contains a peroxide derivative represented by general formula (I) or pharmaceutically acceptable salt thereof as the active ingredient. When used in the form of a percutaneous absorption-type pharmaceutical preparation, the antimalarial acts effectively against malaria because the active ingredient gradually moves into the blood and the effective plasma concentration is sustainable for 12 hours or longer. (In the formula, C is an optionally substituted alicyclic hydrocarbon group and n is an integer of 0 to 6.)
Inventors:
KIM HYE-SOOK (JP)
WATAYA YUSUKE (JP)
SATO AKIRA (JP)
DOI HIROYUKI (JP)
WATAYA YUSUKE (JP)
SATO AKIRA (JP)
DOI HIROYUKI (JP)
Application Number:
PCT/JP2015/079511
Publication Date:
April 28, 2016
Filing Date:
October 20, 2015
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
International Classes:
A61K31/357; A61P33/06
Foreign References:
| JP2000229965A | 2000-08-22 | |||
| JP2003335774A | 2003-11-28 |
Other References:
YUKA NAKAMURA ET AL.: "Keihi Kyushu-gata Maralia-yaku no Kaihatsu Kenkyu", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 133 rd, 2013
NAGWA, S.M. ALY ET AL.: "Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum", PARASITOLOGY RESEARCH, vol. 100, no. 5, 2007, pages 1119 - 1124, XP019491994, ISSN: 0932-0113
SATO, AKIRA ET AL.: "Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl) hexan-1-ol (N-251) and its carboxylic acid derivatives", PARASITOLOGY INTERNATIONAL, vol. 60, no. 4, 2011, pages 488 - 492, XP055167573, ISSN: 1383-5769
NAGWA, S.M. ALY ET AL.: "Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum", PARASITOLOGY RESEARCH, vol. 100, no. 5, 2007, pages 1119 - 1124, XP019491994, ISSN: 0932-0113
SATO, AKIRA ET AL.: "Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl) hexan-1-ol (N-251) and its carboxylic acid derivatives", PARASITOLOGY INTERNATIONAL, vol. 60, no. 4, 2011, pages 488 - 492, XP055167573, ISSN: 1383-5769
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
Download PDF:
Previous Patent: SKIN CARE COMPOSITION FOR EXTERNAL USE
Next Patent: OPTICAL ELEMENT AND IMAGE PICKUP DEVICE
Next Patent: OPTICAL ELEMENT AND IMAGE PICKUP DEVICE