Title:
ANTIMICROBIAL POLYMERIC SURFACES
Document Type and Number:
WIPO Patent Application WO2002085542
Kind Code:
A8
Abstract:
Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99 % of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.
Inventors:
TILLER JOERG C
LIAO CHUN-JEN
LEWIS KIM
KLIBANOV ALEXANDER M
LIAO CHUN-JEN
LEWIS KIM
KLIBANOV ALEXANDER M
Application Number:
PCT/US2002/011983
Publication Date:
December 27, 2002
Filing Date:
April 16, 2002
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
TUFTS COLLEGE (US)
TUFTS COLLEGE (US)
International Classes:
A01N43/40; A61L27/34; A61L27/54; C08F8/44; (IPC1-7): B05D3/10; B32B27/04; B32B27/08; B32B27/30; B32B27/32; B32B27/34; B32B27/36; C08F283/00; C08F283/02; C08F283/04; C08L39/08; C08L67/03; C08L77/06
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