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Title:
ANTIMICROBIAL PRESERVATIVES TO ACHIEVE MULTI-DOSE FORMULATION USING BETA-CYCLODEXTRINS FOR LIQUID DOSAGE FORMS
Document Type and Number:
WIPO Patent Application WO2005082416
Kind Code:
A3
Abstract:
The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient ("API"), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The invention is also directed to pharmaceutical compositions of the compounds of Formula (I) wherein R2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyland a pharmaceutically acceptable cyclodextrin and preservative. Formula (I): In particular, the invention is directed to pharmaceutical compositions of the compound of Formula la, and a pharmaceutically acceptable cyclodextrin and a preservative.

Inventors:
ADAMI ROGER CHRISTOPHER (US)
DAVID FREDERICK (FR)
WOOD JULIA ANN (US)
Application Number:
PCT/IB2005/000100
Publication Date:
July 27, 2006
Filing Date:
January 17, 2005
Export Citation:
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Assignee:
PFIZER PROD INC (US)
ADAMI ROGER CHRISTOPHER (US)
DAVID FREDERICK (FR)
WOOD JULIA ANN (US)
International Classes:
A61K47/10; A61K9/00; A61K47/00; A61K47/40; A61K47/48
Domestic Patent References:
WO2001001955A12001-01-11
WO2003080079A12003-10-02
WO2000012137A12000-03-09
WO2003072141A12003-09-04
WO2003009848A12003-02-06
Foreign References:
EP0119737A21984-09-26
Other References:
LEHNER S J ET AL: "Effect of hydroxypropyl-beta-cyclodextrin on the antimicrobial action of preservatives", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 46, no. 3, 1994, pages 186 - 191, XP008061287, ISSN: 0022-3573
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