Title:
ANTIMICROBIAL PROTEIN CARRIER BASED ON GOLD NANOPARTICLE-APTAMER CONJUGATE AND FABRICATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/234673
Kind Code:
A1
Abstract:
The present invention relates to an antimicrobial peptide carrier, a fabrication method therefor, and an antimicrobial composition containing same, wherein the carrier can efficiently deliver antimicrobial peptides and induce the expression thereof within cells and contains gold nanoparticles and an aptamer binding specifically to the antimicrobial peptides.
Inventors:
LEE KANGSEOK (KR)
BAE JEEHYEON (KR)
YEOM JIHYUN (KR)
SIM SEHOON (KR)
JOO MINJU (KR)
BAE DAYEONG (KR)
LEE JAEMIN (KR)
BAE JEEHYEON (KR)
YEOM JIHYUN (KR)
SIM SEHOON (KR)
JOO MINJU (KR)
BAE DAYEONG (KR)
LEE JAEMIN (KR)
Application Number:
PCT/KR2023/007375
Publication Date:
December 07, 2023
Filing Date:
May 30, 2023
Export Citation:
Assignee:
NES BIOTECHNOLOGY CO LTD (KR)
International Classes:
A61K9/51; A61K38/00; A61K47/69; A61P31/04; C12N15/115
Foreign References:
| KR101966505B1 | 2019-04-05 |
Other References:
PARK JAEYEONG; SHIN EUNKYOUNG; YEOM JI-HYUN; CHOI YOUNKYUNG; JOO MINJU; LEE MINHO; KIM JE HYEONG; BAE JEEHYEON; LEE KANGSEOK: "Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice", THE JOURNAL OF MICROBIOLOGY, THE MICROBIOLOGICAL SOCIETY OF KOREA // HAN-GUG MISAENGMUL HAG-HOE, KR, vol. 60, no. 1, 29 December 2021 (2021-12-29), KR , pages 128 - 136, XP037649880, ISSN: 1225-8873, DOI: 10.1007/s12275-022-1620-3
ELSALEM LINA, KHASAWNEH AYAT, AL SHEBOUL SUHAILA: "WLBU2 Antimicrobial Peptide as a Potential Therapeutic for Treatment of Resistant Bacterial Infections", TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 19, no. 1, 25 February 2022 (2022-02-25), pages 110 - 115, XP093115556, ISSN: 1304-530X, DOI: 10.4274/tjps.galenos.2020.43078
YEOM JI-HYUN; LEE BOEUN; KIM DAEYOUNG; LEE JONG-KOOK; KIM SUK; BAE JEEHYEON; PARK YOONKYUNG; LEE KANGSEOK: "Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellularSalmonella entericaserovar Typhimurium", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 104, 8 July 2016 (2016-07-08), AMSTERDAM, NL , pages 43 - 51, XP029681210, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2016.07.009
BOEUN LEE ET AL: "Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 7, no. 1, 19 October 2017 (2017-10-19), US , pages 1 - 10, XP055705420, ISSN: 2045-2322, DOI: 10.1038/s41598-017-14127-z
ELSALEM LINA, KHASAWNEH AYAT, AL SHEBOUL SUHAILA: "WLBU2 Antimicrobial Peptide as a Potential Therapeutic for Treatment of Resistant Bacterial Infections", TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 19, no. 1, 25 February 2022 (2022-02-25), pages 110 - 115, XP093115556, ISSN: 1304-530X, DOI: 10.4274/tjps.galenos.2020.43078
YEOM JI-HYUN; LEE BOEUN; KIM DAEYOUNG; LEE JONG-KOOK; KIM SUK; BAE JEEHYEON; PARK YOONKYUNG; LEE KANGSEOK: "Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellularSalmonella entericaserovar Typhimurium", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 104, 8 July 2016 (2016-07-08), AMSTERDAM, NL , pages 43 - 51, XP029681210, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2016.07.009
BOEUN LEE ET AL: "Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 7, no. 1, 19 October 2017 (2017-10-19), US , pages 1 - 10, XP055705420, ISSN: 2045-2322, DOI: 10.1038/s41598-017-14127-z
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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