Title:
ANTIPARASITIC OLIGONUCLEOTIDES ACTIVE AGAINST DRUG RESISTANT MALARIA
Document Type and Number:
WIPO Patent Application WO1993013740
Kind Code:
A3
Abstract:
The invention provides methods and materials for antisense oligonucleotide therapy against active pathogenic infection by drug resistant or drug sensitive pathogens, including Plasmodium falciparum.
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Inventors:
RAPAPORT ELIEZER (US)
ZAMECNIK PAUL C (US)
ZAMECNIK PAUL C (US)
Application Number:
PCT/US1992/011202
Publication Date:
September 02, 1993
Filing Date:
December 31, 1992
Export Citation:
Assignee:
WORCESTER FOUND EX BIOLOGY (US)
International Classes:
A61K31/70; A61P31/04; C07H21/04; A61P31/12; A61P33/00; C07K14/445; C12N9/06; C12N9/10; C12N15/113; (IPC1-7): A61K31/70; C12N15/11
Domestic Patent References:
| WO1990000624A1 | 1990-01-25 |
Foreign References:
| US4806463A | 1989-02-21 |
Other References:
PROC. NATL. ACAD. SCI. USA vol. 89, September 1992, pages 8577 - 8580 E. RAPAPORT 'Antimalarial activities of oligodeoxynucleotide phosphorothioates in chloroquine-resistant Plasmodium falciparum'
NUCLEIC ACIDS RESEARCH vol. 19, no. 7, 1991, pages 1613 - 1618 CH. SARTORIUS ET AL. 'Hybridization arrest of the cell-free translation of the malarial dihydrofolate reductase/thymidylate synthetase mRNA by anti-sense oligodeoxyribonucleotides' cited in the application
PARASITOLOGY TODAY vol. 7, no. 4, 1991, pages 90 - 93 C. SARTORIUS ET AL. 'The use of antisense oligonucleotides as chemotherapeutic agents'
J. CELL. BIOCHEM. vol. 41, no. SUP0, 1989, page 133 K. DIX ET AL. 'Synthetic antisense oligonucleotides for trypanosome chemotherapy'
PROC. NATL. ACAD. SCI. USA vol. 86, October 1989, pages 7790 - 7794 S. AGRAWAL ET AL. 'Inhibition of HIV in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues' cited in the application
NUCLEIC ACIDS RESEARCH vol. 18, no. 16, 1990, pages 4711 - 4717 P. VERSPIEREN ET AL. 'Effect of RNA secondary structure and modified bases on the inhibition of trypanosomatid protein synthesis in cell free extracts by antisense oligodeoxynucleotides'
PROC. NATL. ACAD. SCI. USA vol. 84, 1987, pages 8360 - 8364 D. BZIK ET AL. 'Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthetase gene' cited in the application
NUCLEIC ACIDS RESEARCH vol. 19, no. 7, 1991, pages 1613 - 1618 CH. SARTORIUS ET AL. 'Hybridization arrest of the cell-free translation of the malarial dihydrofolate reductase/thymidylate synthetase mRNA by anti-sense oligodeoxyribonucleotides' cited in the application
PARASITOLOGY TODAY vol. 7, no. 4, 1991, pages 90 - 93 C. SARTORIUS ET AL. 'The use of antisense oligonucleotides as chemotherapeutic agents'
J. CELL. BIOCHEM. vol. 41, no. SUP0, 1989, page 133 K. DIX ET AL. 'Synthetic antisense oligonucleotides for trypanosome chemotherapy'
PROC. NATL. ACAD. SCI. USA vol. 86, October 1989, pages 7790 - 7794 S. AGRAWAL ET AL. 'Inhibition of HIV in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues' cited in the application
NUCLEIC ACIDS RESEARCH vol. 18, no. 16, 1990, pages 4711 - 4717 P. VERSPIEREN ET AL. 'Effect of RNA secondary structure and modified bases on the inhibition of trypanosomatid protein synthesis in cell free extracts by antisense oligodeoxynucleotides'
PROC. NATL. ACAD. SCI. USA vol. 84, 1987, pages 8360 - 8364 D. BZIK ET AL. 'Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthetase gene' cited in the application
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