Title:
ANTISENSE MODULATION OF CASEIN KINASE 2-ALPHA EXPRESSION
Document Type and Number:
WIPO Patent Application WO2002062818
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Casein kinase 2-alpha. Methods of using these compounds for modulation of Casein kinase 2-alpha expression and for treatment of diseases associated with expression of Casein kinase 2-alpha are provided.
Inventors:
MCKAY ROBERT (US)
FREIER SUSAN M (US)
WYATT JACQUELINE R (US)
FREIER SUSAN M (US)
WYATT JACQUELINE R (US)
Application Number:
PCT/US2002/002942
Publication Date:
October 03, 2002
Filing Date:
January 31, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
MCKAY ROBERT (US)
FREIER SUSAN M (US)
WYATT JACQUELINE R (US)
MCKAY ROBERT (US)
FREIER SUSAN M (US)
WYATT JACQUELINE R (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Foreign References:
| US5998148A | 1999-12-07 |
Other References:
ULLOA ET AL.: "Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells", THE EMBO JOURNAL, vol. 12, no. 4, 1993, pages 1633 - 1640, XP002952118
PEPPERKOK ET AL.: "Cell growth stimulation by EGF: Inhibition through antisense-oligonucleotides demonstrates important role of casein kinase II", EXPERIMENTAL CELL RESEARCH, vol. 197, 1991, pages 245 - 253, XP002952117
FORMBY ET AL.: "Phosphorylation stabilizes anternatively spliced CD44 mRNA transcripts in breast cancer cells: Inhibition by antisense complementary to casein kinase II mRNA", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 187, 1998, pages 23 - 31, XP002952116
PEPPERKOK ET AL.: "Cell growth stimulation by EGF: Inhibition through antisense-oligonucleotides demonstrates important role of casein kinase II", EXPERIMENTAL CELL RESEARCH, vol. 197, 1991, pages 245 - 253, XP002952117
FORMBY ET AL.: "Phosphorylation stabilizes anternatively spliced CD44 mRNA transcripts in breast cancer cells: Inhibition by antisense complementary to casein kinase II mRNA", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 187, 1998, pages 23 - 31, XP002952116
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