Title:
ANTISENSE OLIGOMER COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/079637
Kind Code:
A3
Abstract:
A modified antisense oligonucleotide of about 10 to about 40 nucleobases is disclosed. The oligonucleotide comprises a targeting sequence having a region complementary to at least one string of three or more identical contiguous nucleobases in a target sequence, wherein the target sequence comprises at least one additional nucleobase compared to the region of the targeting sequence and the at least one additional nucleobase has no complementary nucleobase in the region of the targeting sequence, and wherein the targeting region complementary to the at least one string of three or more identical contiguous nucleobases is internal to the targeting sequence.
Inventors:
SCHNELL FREDERICK J (US)
CAI BAO (US)
GATLIN JASON (US)
IVERSEN PATRICK L (US)
CAI BAO (US)
GATLIN JASON (US)
IVERSEN PATRICK L (US)
Application Number:
PCT/US2018/056572
Publication Date:
June 13, 2019
Filing Date:
October 18, 2018
Export Citation:
Assignee:
SAREPTA THERAPEUTICS INC (US)
International Classes:
C12N15/113; C12N15/11
Foreign References:
| US20030045488A1 | 2003-03-06 | |||
| US20050288246A1 | 2005-12-29 | |||
| US20170029818A1 | 2017-02-02 |
Other References:
DATABASE GenBank [online] 7 February 2017 (2017-02-07), Database accession no. CP018606.1
Attorney, Agent or Firm:
MULHOLLAND, William F. (US)
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