ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR THE TREATMENT OF SCHISTOSOMIASIS

WIPO Patent Application WO1995033759

A3

Antisense oligonucleotides effective at inhibiting protein synthesis of schistosome worms are disclosed. It is shown that these oligonucleotides are efficiently taken up by the schistosome worm and may effectively kill the worms in vivo. Accordingly, these antisense oligonucleotides and methods of their administration may be useful for treating schistosomiasis.

WO/2007/081204	NUCLEIC ACID MOLECULES AND COLLECTIONS THEREOF, THEIR APPLICATION AND MODIFICATION
WO/2022/247873	ENGINEERED CAS12I NUCLEASE, EFFECTOR PROTEIN AND USE THEREOF
WO/2023/119337	SESTRIN-MAPK COMPLEX INHIBITORS

AGRAWAL SUDHIR (US)
TANG JIN-YAN (US)
TAO LIANG-FENG (US)
MARX KENNETH A (US)
COLEMAN ROBERT (US)

PCT/US1995/009598

January 11, 1996

May 30, 1995

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HYBRIDON INC (US)
UNIV MASSACHUSETTS AT LOWELL (US)
AGRAWAL SUDHIR (US)
TANG JIN YAN (US)
TAO LIANG FENG (US)
MARX KENNETH A (US)
COLEMAN ROBERT (US)

C12N15/113; A61K38/00; (IPC1-7): C07H21/00; C12N15/11; A61K48/00

WO1993013740A2

1993-07-22

LIBUSE A. BOBEK ET AL: "Small Gene Family Encoding an Eggshell (Chorion) Protein of the Human Parasite Schistosoma mansoni", MOLECULAR AND CELLULAR BIOLOGY, vol. 8, no. 8, August 1988 (1988-08-01)
LI-LY CHEN ET AL: "Schistosoma mansoni p48 eggshell protein gene: characterization, developmentally regulated expression and comparison to the p14 eggshell protein gene", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 52, 1992, XP024105737, DOI: doi:10.1016/0166-6851(92)90034-H

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