Title:
ANTISENSE OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO/2023/075043
Kind Code:
A1
Abstract:
The present invention relates to novel antisense oligonucleotides comprising at least one modified nucleotide from among oligonucleotides of SEQ ID NOs: 1 to 3. The novel oligonucleotides exhibit an excellent effect of inhibiting the expression of TGF-β2 protein, an excellent effect of killing cancer cells, and improved stability in plasma. Therefore, the oligonucleotides of the present invention can be effectively used as a pharmaceutical composition for treating diseases related to TGF-β2 expression.
Inventors:
KOO JI HYE (KR)
KWON HYE JEONG (KR)
KIM JI-HYE (KR)
PARK JUN EUI (KR)
HONG SOO JEONG (KR)
PARK CHANG HEE (KR)
KIM TAE HUN (KR)
KWON HYE JEONG (KR)
KIM JI-HYE (KR)
PARK JUN EUI (KR)
HONG SOO JEONG (KR)
PARK CHANG HEE (KR)
KIM TAE HUN (KR)
Application Number:
PCT/KR2022/003884
Publication Date:
May 04, 2023
Filing Date:
March 22, 2022
Export Citation:
Assignee:
AUTOTELIC BIO INC (KR)
International Classes:
C12N15/113
Foreign References:
| KR20150140701A | 2015-12-16 | |||
| KR20180103816A | 2018-09-19 | |||
| JP2019167346A | 2019-10-03 | |||
| US20120108646A1 | 2012-05-03 | |||
| US20180251548A1 | 2018-09-06 |
Attorney, Agent or Firm:
KIM, Young-shin (KR)
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