Title:
ANTITUMOR AGENT CONTAINING 4-[[3,5-BIS(TRIMETHYLSILYL)BENZOYL]AMINO]BENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2010/032436
Kind Code:
A1
Abstract:
Disclosed is a novel combination therapy of sorafenib having a remarkable antitumor effect.
Specifically disclosed is an antitumor agent obtained by combining sorafenib or a salt thereof with 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid or a salt thereof.
Inventors:
MURAKAMI KOJI (JP)
Application Number:
PCT/JP2009/004599
Publication Date:
March 25, 2010
Filing Date:
September 15, 2009
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
MURAKAMI KOJI (JP)
MURAKAMI KOJI (JP)
International Classes:
A61K31/695; A61K31/4412; A61P35/00; A61P43/00
Domestic Patent References:
| WO2006125539A2 | 2006-11-30 |
Foreign References:
| JP2005511658A | 2005-04-28 | |||
| JP3845792B2 | 2006-11-15 | |||
| JP2005511658A | 2005-04-28 | |||
| JP2761023B2 | 1998-06-04 |
Other References:
FUMIHIKO NAKAI ET AL.: "Kansaibogan ni Taisuru Bunshi Hyotekiyaku no Kaihatsu Jokyo", KAN-TAN- SUI, vol. 55, no. 5, 2007, pages 861 - 866, XP008144112
SHINJI OIE ET AL.: "Hito Kansaibogan Yuraikabu JHH-7 no Bunshi Seibutsugakuteki Tokucho to RAR-a Tokuiteki Ketsugosei o Yusuru Kagobutsu TAC-101 ni Taisuru Hannosei", THE CELL, vol. 33, no. 11, 2001, pages 428 - 431, XP003011664
MURAKAMI, K. ET AL.: "4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals", CLIN EXP METASTASIS, vol. 16, no. 7, 1998, pages 633 - 643, XP003001314
NATURE REVIEWS DRUG DISCOVERY, vol. 5, no. 10, 2006, pages 835 - 44
ANNALS OF ONCOLOGY, vol. 17, no. 5, 2006, pages 866 - 873
CLINICAL CANCER RESEARCH, vol. 12, no. 1, 2006, pages 144 - 51
J. CLIN. ONCOL, vol. 20, no. 16, 2002, pages 3522 - 3532
SHINJI OIE ET AL.: "Hito Kansaibogan Yuraikabu JHH-7 no Bunshi Seibutsugakuteki Tokucho to RAR-a Tokuiteki Ketsugosei o Yusuru Kagobutsu TAC-101 ni Taisuru Hannosei", THE CELL, vol. 33, no. 11, 2001, pages 428 - 431, XP003011664
MURAKAMI, K. ET AL.: "4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals", CLIN EXP METASTASIS, vol. 16, no. 7, 1998, pages 633 - 643, XP003001314
NATURE REVIEWS DRUG DISCOVERY, vol. 5, no. 10, 2006, pages 835 - 44
ANNALS OF ONCOLOGY, vol. 17, no. 5, 2006, pages 866 - 873
CLINICAL CANCER RESEARCH, vol. 12, no. 1, 2006, pages 144 - 51
J. CLIN. ONCOL, vol. 20, no. 16, 2002, pages 3522 - 3532
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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