Title:
ANTITUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/2011/129365
Kind Code:
A1
Abstract:
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition metal complex that is represented by general formula (1). In general formula (1), it is preferable that the phosphine ligand is an (S,S)-2,3-bisphosphinoquinoxaline derivative. It is particularly preferable that the phosphine ligand is an (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline. (In the formula, R1 and R2 each represents a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl group having a substituent, an adamantyl group, a phenyl group or a phenyl group having a substituent and has 1-10 carbon atoms; R1 and R2 are different from each other, and R1 has a higher priority than R2 as ranked in accordance with the RS system; R3 and R4 each represents a hydrogen atom, or a linear or branched alkyl group and has 1-6 carbon atoms; R3 and R4 may be the same groups or different groups; R3 and R4 may combine together to form a saturated or unsaturated ring, and the saturated or unsaturated ring may have a substituent; M represents a transition metal atom that is selected from the group consisting of gold, copper and silver; and X- represents an anion.)
Inventors:
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
MAYAMA DAISUKE (JP)
NAKATSUI KAZUHIRO (JP)
MAYAMA DAISUKE (JP)
Application Number:
PCT/JP2011/059179
Publication Date:
October 20, 2011
Filing Date:
April 13, 2011
Export Citation:
Assignee:
NIPPON CHEMICAL IND (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
MAYAMA DAISUKE (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
MAYAMA DAISUKE (JP)
International Classes:
A61K31/555; A61K31/4965; A61K31/498; A61K31/66; A61P35/00; A61P35/02; A61P35/04; C07B53/00; C07B57/00; C07F1/12
Foreign References:
| JP2007320909A | 2007-12-13 | |||
| JP2001253889A | 2001-09-18 | |||
| JP2003300988A | 2003-10-21 | |||
| JP2007056007A | 2007-03-08 | |||
| JP2010138136A | 2010-06-24 |
Other References:
IMAMOTO, T. ET AL.: "Improved synthetic routes to methylene-bridged P-chiral diphosphine ligands via secondary phosphine- boranes", TETRAHEDRON: ASYMMETRY, vol. 21, no. 11-12, June 2010 (2010-06-01), pages 1522 - 1528
Attorney, Agent or Firm:
NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP)
Nippon Chemical Industrial Co., Ltd. (JP)
Nippon Chemical Industrial Co., Ltd. (JP)
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