Title:
ANTITUMOR AGENTS
Document Type and Number:
WIPO Patent Application WO/1999/004776
Kind Code:
A1
Abstract:
Antitumor agents containing as the active ingredient a compound selected from among pallidol, miyabenol A, miyabenol C, $g(a)-viniferin, kobophenol A, 4,4-(1,3-butadiene-1,4-diyl)bisphenol, leachianol A, leachianol B, leachianol F, leachianol G, hopeaphenol and davidiol A and salts thereof. Because of having excellent topoisomerase II inhibitory effects, these compounds are usable as antitumor agents.
Inventors:
NOZAKI HIROSHI (JP)
IINUMA MUNEKAZU (JP)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
IINUMA MUNEKAZU (JP)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
Application Number:
PCT/JP1998/003273
Publication Date:
February 04, 1999
Filing Date:
July 22, 1998
Export Citation:
Assignee:
MEIJI MILK PROD CO LTD (JP)
NOZAKI HIROSHI (JP)
IINUMA MUNEKAZU (JP)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
NOZAKI HIROSHI (JP)
IINUMA MUNEKAZU (JP)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
International Classes:
C07D307/80; A61K31/045; A61K31/047; A61K31/05; A61K31/12; A61K31/122; A61K31/34; A61K31/343; A61K31/352; A61K36/18; A61K36/48; A61P35/00; A61P43/00; C07D307/93; (IPC1-7): A61K31/05; A61K31/34
Domestic Patent References:
| WO1994021598A1 | 1994-09-29 | |||
| WO1993022319A1 | 1993-11-11 | |||
| WO1990009788A1 | 1990-09-07 |
Foreign References:
| EP0657458A1 | 1995-06-14 | |||
| EP0541486A1 | 1993-05-12 | |||
| JPH05213769A | 1993-08-24 | |||
| JPH02289531A | 1990-11-29 | |||
| US5332811A | 1994-07-26 |
Other References:
XU G., ET AL.: "INHIBITION OF PROTEIN KINASE C BY STILBENOIDS.", YAO HSUEH HSUEH PAO - ACTA PHARMACEUTICA SINICA., YAOXUE XUEBAO, CN, vol. 29., no. 11., 1 January 1994 (1994-01-01), CN, pages 818 - 822., XP002914695, ISSN: 0513-4870
KULANTHAIVEL P., ET AL.: "NATURALLY OCCURRING PROTEIN KINASE C INHIBITORS; II. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA SINICA.", PLANTA MEDICA, THIEME VERLAG, DE, vol. 61., no. 01., 1 January 1995 (1995-01-01), DE, pages 41 - 44., XP002912936, ISSN: 0032-0943
See also references of EP 0998924A4
KULANTHAIVEL P., ET AL.: "NATURALLY OCCURRING PROTEIN KINASE C INHIBITORS; II. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA SINICA.", PLANTA MEDICA, THIEME VERLAG, DE, vol. 61., no. 01., 1 January 1995 (1995-01-01), DE, pages 41 - 44., XP002912936, ISSN: 0032-0943
See also references of EP 0998924A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku Tokyo, JP)
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