Title:
ANTITUMOR AGENTS
Document Type and Number:
WIPO Patent Application WO/2002/092096
Kind Code:
A1
Abstract:
It has been confirmed that antitumor agents containing as the active ingredient (3R)-N-(1-(1-tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea favorably inhibit the proliferation of cancer in various cancer-carrying mice and have a low toxicity. These agents are particularly useful in treating pancreatic cancer, intestinal cancer and gastric cancer. In case of using these drugs in polypharmaceutical chemotherapy, the administration dose of an antitumor agent having strong side effects can be lowered. It is therefore expected that polypharmaceutical chemotherapy achieving a favorable antitumor effect and relieved side effects can be thus embodied.
Inventors:
YAMANO MAYUMI (JP)
Application Number:
PCT/JP2002/004482
Publication Date:
November 21, 2002
Filing Date:
May 08, 2002
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
YAMANO MAYUMI (JP)
YAMANO MAYUMI (JP)
International Classes:
A61K31/55; A61K31/5513; A61P35/00; C07D243/14; C07D401/04; C07D403/04; (IPC1-7): A61K31/5513; A61P35/00
Domestic Patent References:
| WO1995006040A1 | 1995-03-02 | |||
| WO1993016999A1 | 1993-09-02 | |||
| WO1998002419A1 | 1998-01-22 | |||
| WO1998000404A1 | 1998-01-08 | |||
| WO1996028416A1 | 1996-09-19 |
Foreign References:
| JPH0840908A | 1996-02-13 |
Other References:
See also references of EP 1391203A4
Attorney, Agent or Firm:
Nagai, Shozo c/o Yamanouchi Pharmaceutical Co. Ltd. (Patent Department, 17-1, Hasune 3-chom, Itabashi-ku Tokyo, JP)
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