Title:
ANTITUMOR COMPOSITIONS CONTAINING TAXANE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002074289
Kind Code:
A3
Abstract:
A pharmaceutical composition comprised of acetocyclorpropyl taxotere or a derivative thereof, and at least one of an alkylating agent, an antimetabolite, a spindle poison, an epidophyllotoxin, an antibiotic, and enzyme, a topoisomerase inhibitor, a plantinum coordination complex, a biological response modifier or a growth factor inhibitor is described.
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Inventors:
BISSERY MARIE-CHRISTINE (FR)
Application Number:
PCT/IB2002/000853
Publication Date:
September 02, 2004
Filing Date:
March 21, 2002
Export Citation:
Assignee:
AVENTIS PHARMA SA (FR)
BISSERY MARIE-CHRISTINE (FR)
BISSERY MARIE-CHRISTINE (FR)
International Classes:
A61K45/00; A61K31/337; A61K31/4375; A61K31/4745; A61K31/555; A61K31/565; A61K31/704; A61K31/7064; A61K33/243; A61K38/43; A61P35/00; A61P43/00; (IPC1-7): A61K31/337; A61P35/00
Domestic Patent References:
| WO1994010995A1 | 1994-05-26 |
Foreign References:
| EP0827745A1 | 1998-03-11 | |||
| EP0982028A1 | 2000-03-01 |
Other References:
GELMON K.A. ET AL: "Phase I Dose-Finding Study of a New Taxane, RPR 109881A, Administered as a One-Hour Intravenous Infusion Days 1 and 8 to Patients With Advanced Solid Tumors", JOURNAL OF CLINICAL ONCOLOGY, vol. 18, no. 24, 15 December 2000 (2000-12-15), pages 4098 - 4108, XP008010641
KURATA T. ET AL: "Phase I and Pharmacokinetic Study of a New Taxoid, RPR 109881A, Given as a 1-Hour Intravenous Infusion in Patients With Advanced Solid Tumors", JOURNAL OF CLINICAL ONCOLOGY, vol. 18, no. 17, September 2000 (2000-09-01), pages 3164 - 3171, XP008010639
LOPES N.M. ET AL: "ASSESSMENT OF MICROTUBULE STABILIZERS BY SEMIAUTOMATED IN VITRO MICROTUBULE PROTEIN POLYMERIZATION AND MITOTIC BLOCK ASSAYS", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 41, no. 1, 1997, pages 37 - 47, XP000869505, ISSN: 0344-5704
JOHNSON R.A. ET AL: "TAXOL CHEMISTRY. 7-O-TRIFLATES AS PRECURSORS TO OLEFINS AND CYCLOPROPANES", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 35, no. 43, 1994, pages 7893 - 7896, XP000995197, ISSN: 0040-4039
BUDAVARI S. ET AL: "The Merck Index, 13th edition", 2001, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, NJ, USA, XP002220996
KURATA T. ET AL: "Phase I and Pharmacokinetic Study of a New Taxoid, RPR 109881A, Given as a 1-Hour Intravenous Infusion in Patients With Advanced Solid Tumors", JOURNAL OF CLINICAL ONCOLOGY, vol. 18, no. 17, September 2000 (2000-09-01), pages 3164 - 3171, XP008010639
LOPES N.M. ET AL: "ASSESSMENT OF MICROTUBULE STABILIZERS BY SEMIAUTOMATED IN VITRO MICROTUBULE PROTEIN POLYMERIZATION AND MITOTIC BLOCK ASSAYS", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 41, no. 1, 1997, pages 37 - 47, XP000869505, ISSN: 0344-5704
JOHNSON R.A. ET AL: "TAXOL CHEMISTRY. 7-O-TRIFLATES AS PRECURSORS TO OLEFINS AND CYCLOPROPANES", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 35, no. 43, 1994, pages 7893 - 7896, XP000995197, ISSN: 0040-4039
BUDAVARI S. ET AL: "The Merck Index, 13th edition", 2001, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, NJ, USA, XP002220996
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