Title:
ANTITUMOR COMPOUND NSC-LSC1 AND PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/1993/002067
Kind Code:
A1
Abstract:
A taxol analog represented by estimated structural formula (I). It is one of the structural isomers of taxol and intensely inhibits the growth of mouse and human cancer cells. The production process comprises tissue culture of albumens of a plant belonging to the genus Taxus.
Inventors:
SAITO KOJI (JP)
OHASHI HIROAKI (JP)
TAHARA MAKOTO (JP)
SAKAMOTO TETSUO (JP)
OHASHI HIROAKI (JP)
TAHARA MAKOTO (JP)
SAKAMOTO TETSUO (JP)
Application Number:
PCT/JP1992/000917
Publication Date:
February 04, 1993
Filing Date:
July 17, 1992
Export Citation:
Assignee:
NIPPON STEEL CORP (JP)
International Classes:
C07D305/14; (IPC1-7): A61K31/335; A61K35/78; C07D305/14; C12P17/02
Foreign References:
| US5019504A | 1991-05-28 |
Other References:
Journal of Natural Products, Vol. 49, No. 4, pages 665-669, 1986, C.H. OLIVER HUANG, D.G.I. KINGSTON et al., "New Taxanes from Taxus Breuifolia, 2".
Journal of Organic Chemistry, Vol. 54, No. 8, pages 1805-1810, 1989, G.L. GORDON et al. "Ring expansion of (2+2) Photoaducts".
See also references of EP 0555485A4
Journal of Organic Chemistry, Vol. 54, No. 8, pages 1805-1810, 1989, G.L. GORDON et al. "Ring expansion of (2+2) Photoaducts".
See also references of EP 0555485A4
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