Title:
ANTITUMOR PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/100535
Kind Code:
A1
Abstract:
An antitumor pharmaceutical composition and an application thereof. Active ingredients of the antitumor pharmaceutical composition contain a polyethylene glycol-modified camptothecin derivative (in particular, polyethylene glycol-modified irinotecan) and temozolomide. It is proved by means of animal experiments that the administration of polyethylene glycol-modified camptothecin derivative (in particular, polyethylene glycol-modified irinotecan) and temozolomide in combination has an extremely strong treatment effect on tumors (such as neuroblastoma), and the tumor inhibition rate can reach 98% and is significantly superior to that of a monotherapy group; thus, the provided antitumor pharmaceutical composition has better application prospects for treatment of tumors.
Inventors:
WANG QINGBIN (CN)
SHI JUAN (CN)
HU JINGYUN (CN)
ZHAO XUAN (CN)
SHI JUAN (CN)
HU JINGYUN (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2021/129184
Publication Date:
May 19, 2022
Filing Date:
November 08, 2021
Export Citation:
Assignee:
JENKEM TECH CO LTD TIANJIN (CN)
International Classes:
A61K31/4745; A61K31/4188; A61K47/60; A61P35/00
Domestic Patent References:
| WO2001054678A2 | 2001-08-02 |
Foreign References:
| CN112263579A | 2021-01-26 | |||
| CN104524588A | 2015-04-22 | |||
| CN103083680A | 2013-05-08 |
Other References:
PALMERINI E., JONES R. L., SETOLA E., PICCI P., MARCHESI E., LUKSCH R., GRIGNANI G., CESARI M., LONGHI A., ABATE M. E., PAIOLI A.,: "Irinotecan and temozolomide in recurrent Ewing sarcoma: an analysis in 51 adult and pediatric patients", ACTA ONCOLOGICA., INFORMA HEALTHCARE, LONDON, GB, vol. 57, no. 7, 3 July 2018 (2018-07-03), GB , pages 958 - 964, XP055930636, ISSN: 0284-186X, DOI: 10.1080/0284186X.2018.1449250
XU JIANPING, SHI YUAN-KAI, ZHANG XIANG-RU, LI JUN-LING, HONG-YU WANG, YAN WANG, HAO XUE-ZHI: "Efficacy and Safety of Temozolomide in Combination with Irinotecan in Non-Small Cell Lung Cancer Patients with Relapsed/refractory Brain Metastasis", CLINICAL MEDICATION JOURNAL, vol. 12, no. 5, 30 September 2014 (2014-09-30), pages 27 - 30, XP055930625, ISSN: 1672-3384, DOI: 10.3969/j.issn.1672-3384.2014.05.006
LIU JINGJING, SUN YANLING;DU SHUXU;LI CHUNDE;WU WANSHUI;SUN LIMING: "Clinical Efficacy of Irinotecan and Temozolomide in Treatment of Refractory and Recurrent Child Medulloblastoma", SHANDONG YIYAO - SHANDONG MEDICAL JOURNAL, SHANDONG SHENG WEISHENGTING,, CN, vol. 59, no. 12, 31 December 2019 (2019-12-31), CN , pages 27 - 30, XP055930628, ISSN: 1002-266X, DOI: 10.3969/j.issn.1002-266X.2019.12.007
LIU WEI, DONGQIANG LAN: "tudy on the relationship between the hypermethylation state of MGMT in SK-N-SH induced by temozolomide and irinotecan sensitivity", ANTI-TUMOR PHARMACY, EDITORIAL DEPARTMENT OF ANTI-TUMOR PHARMACY, CN, vol. 1, no. 2, 30 April 2011 (2011-04-30), CN , XP055930632, ISSN: 2095-1264
"Burger's Medicinal Chemistry and Drug Discovery", 2001, WILEY
"Design and Applications of Prodrugs", 1985, HARWOOD ACADEMIC PUBLISHERS
See also references of EP 4230205A4
XU JIANPING, SHI YUAN-KAI, ZHANG XIANG-RU, LI JUN-LING, HONG-YU WANG, YAN WANG, HAO XUE-ZHI: "Efficacy and Safety of Temozolomide in Combination with Irinotecan in Non-Small Cell Lung Cancer Patients with Relapsed/refractory Brain Metastasis", CLINICAL MEDICATION JOURNAL, vol. 12, no. 5, 30 September 2014 (2014-09-30), pages 27 - 30, XP055930625, ISSN: 1672-3384, DOI: 10.3969/j.issn.1672-3384.2014.05.006
LIU JINGJING, SUN YANLING;DU SHUXU;LI CHUNDE;WU WANSHUI;SUN LIMING: "Clinical Efficacy of Irinotecan and Temozolomide in Treatment of Refractory and Recurrent Child Medulloblastoma", SHANDONG YIYAO - SHANDONG MEDICAL JOURNAL, SHANDONG SHENG WEISHENGTING,, CN, vol. 59, no. 12, 31 December 2019 (2019-12-31), CN , pages 27 - 30, XP055930628, ISSN: 1002-266X, DOI: 10.3969/j.issn.1002-266X.2019.12.007
LIU WEI, DONGQIANG LAN: "tudy on the relationship between the hypermethylation state of MGMT in SK-N-SH induced by temozolomide and irinotecan sensitivity", ANTI-TUMOR PHARMACY, EDITORIAL DEPARTMENT OF ANTI-TUMOR PHARMACY, CN, vol. 1, no. 2, 30 April 2011 (2011-04-30), CN , XP055930632, ISSN: 2095-1264
"Burger's Medicinal Chemistry and Drug Discovery", 2001, WILEY
"Design and Applications of Prodrugs", 1985, HARWOOD ACADEMIC PUBLISHERS
See also references of EP 4230205A4
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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