Title:
ANTITUSSIVES
Document Type and Number:
WIPO Patent Application WO/2004/026292
Kind Code:
A1
Abstract:
Antitussives containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) (wherein A is alkoxycarbonylalkyl or the like and R is optionally protected hydroxyl, or A and R may be united to form a six- or seven-membered oxygenic ring; B is carbonyl or sulfonyl; R1 and R2 are each hydrogen or the like; R3 and R4 are each hydrogen or the like, or R3 and R4 may be united to from alkylenedioxy; and n is 1 or 2). The invention provides novel compounds having antitussive activity, particularly peripheral antitussive activity.
Inventors:
KAMEI JUNZO (JP)
IGARASHI YASUSHI (JP)
HIBINO TOMOKO (JP)
AOKI KATSUYUKI (JP)
OKUBO TORU (JP)
IGARASHI YASUSHI (JP)
HIBINO TOMOKO (JP)
AOKI KATSUYUKI (JP)
OKUBO TORU (JP)
Application Number:
PCT/JP2003/011615
Publication Date:
April 01, 2004
Filing Date:
September 11, 2003
Export Citation:
Assignee:
TSUMURA & CO (JP)
KAMEI JUNZO (JP)
IGARASHI YASUSHI (JP)
HIBINO TOMOKO (JP)
AOKI KATSUYUKI (JP)
OKUBO TORU (JP)
KAMEI JUNZO (JP)
IGARASHI YASUSHI (JP)
HIBINO TOMOKO (JP)
AOKI KATSUYUKI (JP)
OKUBO TORU (JP)
International Classes:
A61K31/166; A61K31/18; A61K31/197; A61K31/198; A61K31/22; A61K31/223; A61K31/33; A61K31/357; A61K31/36; A61K31/4406; A61K31/4409; A61K31/4425; A61K31/5355; A61K31/536; A61K31/553; A61P11/00; A61P11/08; A61P11/14; C07C235/60; C07D207/335; C07D209/14; C07D213/42; C07D213/89; C07D215/12; C07D265/26; C07D267/14; C07D277/28; C07D291/08; C07D307/52; C07D317/58; C07D319/18; C07D333/20; C07D413/06; C07D419/06; C07D207/32; (IPC1-7): A61K31/166; A61K31/18; A61K31/197; A61K31/198; A61K31/22; A61K31/223; A61K31/33; A61K31/357; A61K31/36; A61K31/4406; A61K31/4409; A61K31/4425; A61K31/5355; A61K31/536; A61K31/553; A61P11/00; A61P11/08; A61P11/14; C07C235/60; C07C311/29; C07C311/37; C07D213/38; C07D213/42; C07D213/89; C07D265/22; C07D265/26; C07D267/14; C07D291/08; C07D317/58; C07D319/18; C07D413/06; C07D419/06
Foreign References:
| EP0127066A2 | 1984-12-05 |
Other References:
SUPURAN C.T. ET AL.: "Protease inhibitors: synthesis of L-alanin hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase", JOURNAL OF ENZYME INHIBITION, vol. 15, no. 2, 2000, pages 111 - 128, XP002975844
SCOZZAFAVA A. ET AL.: "protease inhibitors-Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido-glycine hydroxamate inhibitors of clostridium histolyticum collagenase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 3, 2000, pages 299 - 307, XP000999628
SCOZZAFAVA A. ET AL.: "Protease inhibitors. Part 8: Synthesis of potent clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 3, 2000, pages 637 - 645, XP002975845
SUPURAN C.T. ET AL.: "Protease inhibitors. Part 7: Inhibition of clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 10, no. 1, 2000, pages 67 - 76, XP002235652
SCOZZAFAVA A. ET AL.: "protease inhibitors-Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido-glycine hydroxamate inhibitors of clostridium histolyticum collagenase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 3, 2000, pages 299 - 307, XP000999628
SCOZZAFAVA A. ET AL.: "Protease inhibitors. Part 8: Synthesis of potent clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 3, 2000, pages 637 - 645, XP002975845
SUPURAN C.T. ET AL.: "Protease inhibitors. Part 7: Inhibition of clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 10, no. 1, 2000, pages 67 - 76, XP002235652
Attorney, Agent or Firm:
Ono, Nobuo (1-13-1 Kandaizumi-ch, Chiyoda-ku Tokyo, JP)
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