Title:
ANTIVIRAL NUCLEOSIDE ANALOGUE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/202604
Kind Code:
A1
Abstract:
The present invention falls within the technical field of medicinal chemistry, and specifically relates to an antiviral nucleoside analogue, and a pharmaceutical composition and the use thereof. The nucleoside analogue of the present invention has a structure as represented by formula (I), and has a good chemical stability, a high oral bioavailability, and a significant antiviral activity. The nucleoside analogue can be used in the preparation of an inhibitor for inhibiting viral replication and/or a drug for preventing, alleviating and/or treating diseases caused by viral infection.
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Inventors:
SHEN JINGSHAN (CN)
XIE YUANCHAO (CN)
ZHANG LEIKE (CN)
CHENG YONG (CN)
TIAN GUANGHUI (CN)
XIAO GENGFU (CN)
LI JIAN (CN)
YU JINGJIN (CN)
XIE YUANCHAO (CN)
ZHANG LEIKE (CN)
CHENG YONG (CN)
TIAN GUANGHUI (CN)
XIAO GENGFU (CN)
LI JIAN (CN)
YU JINGJIN (CN)
Application Number:
PCT/CN2023/089155
Publication Date:
October 26, 2023
Filing Date:
April 19, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
VIGONVITA LIFE SCIENCES CO LTD (CN)
WUHAN INST VIROLOGY CAS (CN)
VIGONVITA SHANGHAI CO LTD (CN)
VIGONVITA LIFE SCIENCES CO LTD (CN)
WUHAN INST VIROLOGY CAS (CN)
VIGONVITA SHANGHAI CO LTD (CN)
International Classes:
C07D405/04; A61K31/505; A61P31/14; C07H19/10
Domestic Patent References:
| WO2016182939A1 | 2016-11-17 | |||
| WO2016182935A1 | 2016-11-17 | |||
| WO2022174179A1 | 2022-08-18 |
Foreign References:
| CN112074506A | 2020-12-11 | |||
| CN112778310A | 2021-05-11 | |||
| CN114096543A | 2022-02-25 | |||
| CN115215914A | 2022-10-21 | |||
| US5840743A | 1998-11-24 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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