Title:
APOPTOSIS INDUCER
Document Type and Number:
WIPO Patent Application WO/1999/029647
Kind Code:
A1
Abstract:
Apoptosis inducers represented by chemical formulae (I), (II), (VIII), (IV), (V), (VI), (III) and (VII); and medicinal compositions containing the same and usable as carcinostatic and the like.
Inventors:
ENOKI TATSUJI (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
KATO IKUNOSHIN (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
KATO IKUNOSHIN (JP)
Application Number:
PCT/JP1998/005554
Publication Date:
June 17, 1999
Filing Date:
December 08, 1998
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
ENOKI TATSUJI (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
KATO IKUNOSHIN (JP)
ENOKI TATSUJI (JP)
KOYAMA NOBUTO (JP)
IKAI KATSUSHIGE (JP)
KATO IKUNOSHIN (JP)
International Classes:
C07C45/60; C07C49/493; C07C49/707; C07C49/753; C07C233/25; C07D213/65; C07D233/60; C07D233/64; C07D521/00; (IPC1-7): C07C49/707; A61K31/12; A61K31/165; A61K31/415; A61K31/44; A61K31/495; C07C49/753; C07C229/08; C07C233/25; C07D213/65; C07D233/60; C07D513/18
Domestic Patent References:
| WO1993000066A1 | 1993-01-07 | |||
| WO1998039291A1 | 1998-09-11 | |||
| WO1998040346A1 | 1998-09-17 |
Foreign References:
| JPS56102851A | 1981-08-17 | |||
| US3381691A | 1968-05-07 |
Other References:
ARNAU N., ET AL.: "PALLADIUM (O)-CATALYZED ALLYLATION OF HETEROCYCLES WITH CYCLOPENTENE DERIVATIVES.LLYLATION OF HETEROCYCLES WITH", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 34., no. 01., 1 January 1997 (1997-01-01), US, pages 233 - 239., XP002920022, ISSN: 0022-152X, DOI: 10.1002/jhet.5570340135
SAVILLE-STONES E. A., ET AL.: "SYNTHESIS OF (PLUS OR MINUS)-2',3'-DIDEHYDRO-2',3'-DIDEOXY NUCLEOSIDES VIA A MODIFIED PRINS REACTION AND PALLADIUM(O) CATALYSED COUPLING.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 10., 1 January 1991 (1991-01-01), GB, pages 2603/2604., XP002920023, ISSN: 0300-922X, DOI: 10.1039/p19910002603
SAKAI S., ET AL.: "TRANSLOCATION AND METABOLISM OF A SEED FUNGICIDE, PEFURAZOATE, IN RICE SEEDLINGS.", JOURNAL OF PESTICIDE SCIENCE., PESTICIDE SCIENCE SOCIETY, TOKYO., JP, vol. 18., no. 03., 1 January 1993 (1993-01-01), JP, pages 217 - 233., XP002920024, ISSN: 0916-9962
NORRIS D. J., STEWART R.: "THE PYRIDINIUM-DIHYDROPYRIDINE SYSTEM. I. SYNTHESIS OF A SERIES OF SUBSTITUTED PYRIDINIUM IONS AND THEIR 1,4-DIHYDRO REDUCTION PRODUCTS AND A DETERMINATION OF THEIR STABILITIES IN AQUEOUS BUFFERS.", CANADIAN JOURNAL OF CHEMISTRY, NRC RESEARCH PRESS, CA, vol. 55., no. 10., 1 January 1977 (1977-01-01), CA, pages 1687 - 1695., XP002920025, ISSN: 0008-4042, DOI: 10.1139/v77-238
GROENNEBERG T., UNDHEIM K.: "N-QUATERNARY COMPOUNDS. PART XXV. IONIZATION CONSTANTS OF PYRIDINIUM-3-OXIDES.", ACTA CHEMICA SCANDINAVICA., MUNKSGAARD, COPENHAGEN., DK, vol. 26., no. 05., 1 January 1972 (1972-01-01), DK, pages 1847 - 1850., XP002920026, ISSN: 0904-213X
See also references of EP 1048641A4
SAVILLE-STONES E. A., ET AL.: "SYNTHESIS OF (PLUS OR MINUS)-2',3'-DIDEHYDRO-2',3'-DIDEOXY NUCLEOSIDES VIA A MODIFIED PRINS REACTION AND PALLADIUM(O) CATALYSED COUPLING.", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 10., 1 January 1991 (1991-01-01), GB, pages 2603/2604., XP002920023, ISSN: 0300-922X, DOI: 10.1039/p19910002603
SAKAI S., ET AL.: "TRANSLOCATION AND METABOLISM OF A SEED FUNGICIDE, PEFURAZOATE, IN RICE SEEDLINGS.", JOURNAL OF PESTICIDE SCIENCE., PESTICIDE SCIENCE SOCIETY, TOKYO., JP, vol. 18., no. 03., 1 January 1993 (1993-01-01), JP, pages 217 - 233., XP002920024, ISSN: 0916-9962
NORRIS D. J., STEWART R.: "THE PYRIDINIUM-DIHYDROPYRIDINE SYSTEM. I. SYNTHESIS OF A SERIES OF SUBSTITUTED PYRIDINIUM IONS AND THEIR 1,4-DIHYDRO REDUCTION PRODUCTS AND A DETERMINATION OF THEIR STABILITIES IN AQUEOUS BUFFERS.", CANADIAN JOURNAL OF CHEMISTRY, NRC RESEARCH PRESS, CA, vol. 55., no. 10., 1 January 1977 (1977-01-01), CA, pages 1687 - 1695., XP002920025, ISSN: 0008-4042, DOI: 10.1139/v77-238
GROENNEBERG T., UNDHEIM K.: "N-QUATERNARY COMPOUNDS. PART XXV. IONIZATION CONSTANTS OF PYRIDINIUM-3-OXIDES.", ACTA CHEMICA SCANDINAVICA., MUNKSGAARD, COPENHAGEN., DK, vol. 26., no. 05., 1 January 1972 (1972-01-01), DK, pages 1847 - 1850., XP002920026, ISSN: 0904-213X
See also references of EP 1048641A4
Attorney, Agent or Firm:
Adati, Mituo (6th floor 6-20, Tosabori 1-chome Nishi-ku Osaka-shi Osaka, JP)
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