Title:
APOPTOSIS INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1999/031037
Kind Code:
A1
Abstract:
Apoptosis inhibitors containing as the active ingredient compounds represented by general formula (I) or salts thereof, wherein W¿1? represents -O-, -CH¿2?-, etc.; W¿2? represents -CH¿2?-, etc.; W¿3? represents -O-, -CH¿2?-, etc.; X represents CH, C?-¿, etc.; and A represents formula ($g(a)) wherein W¿4? represents -O-, -CH¿2?-, etc.; W¿5? represents -CH¿2?-, etc.; and W¿6? represents -O-, -CH¿2?-, etc. These apoptosis inhibitors inhibit apoptosis of WC8 cells induced by Fas ligand. In animal models, they potently inhibit the progress of fulminant hepatitis and relieve alopecia caused by anticancer agents. Because of being highly safe, these apoptosis inhibitors are usable as beneficial drugs.
Inventors:
KATO KAZUO (JP)
SATOH TSUTOMU (JP)
SAITOH FUMIHIKO (JP)
TAKIGUCHI KAZUHIKO (JP)
TSUDA TOSHIHIKO (JP)
SATOH TSUTOMU (JP)
SAITOH FUMIHIKO (JP)
TAKIGUCHI KAZUHIKO (JP)
TSUDA TOSHIHIKO (JP)
Application Number:
PCT/JP1998/005663
Publication Date:
June 24, 1999
Filing Date:
December 15, 1998
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
KATO KAZUO (JP)
SATOH TSUTOMU (JP)
SAITOH FUMIHIKO (JP)
TAKIGUCHI KAZUHIKO (JP)
TSUDA TOSHIHIKO (JP)
KATO KAZUO (JP)
SATOH TSUTOMU (JP)
SAITOH FUMIHIKO (JP)
TAKIGUCHI KAZUHIKO (JP)
TSUDA TOSHIHIKO (JP)
International Classes:
A61K31/075; A61K31/09; A61K31/10; A61K31/122; A61K31/357; A61K31/366; A61K31/382; A61K31/397; A61K31/4025; A61K31/4178; A61K31/4433; A61K31/453; A61K31/496; A61K31/5377; A61K31/55; C07C45/45; C07C45/51; C07C45/75; C07C49/417; C07C49/517; C07C49/723; C07C49/753; C07C323/12; C07D309/38; C07D319/06; C07D319/16; C07D335/02; C07D405/06; C07D495/10; C07D519/00; C07D521/00; (IPC1-7): C07C49/417; A61K31/12; A61K31/335; A61K31/37; A61K31/38; C07C49/517; C07C323/12; C07D309/32; C07D319/06; C07D319/08; C07D335/02; C07D405/06; C07D407/06; C07D495/10
Foreign References:
| US4065440A | 1977-12-27 | |||
| JPH0586225A | 1993-04-06 |
Other References:
EBERLE M, LAWTON R G: "THIOALKYLATION OF MELDRUM'S ACID: PROTECTED ALKYLIDENE DERIVATIVES OF ISOPROPYLIDENE MALONATE", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., CH, vol. 71, no. 08, 1 January 1988 (1988-01-01), CH, pages 1974 - 1982, XP002926106, ISSN: 0018-019X, DOI: 10.1002/hlca.19880710816
MOEHRLE H, SCHALTENBRAND R: "AMINOMETHYLIERUNG VON 1,3-DIKETONEN", PHARMAZIE, vol. 40, no. 10, 1 January 1985 (1985-01-01), pages 697 - 701, XP002926107, ISSN: 0031-7144
KASAHARA Y, MIYAWAKI T: "APOTOOSHISU NI OKERU FAS/APO-1 KOUGEN (CD95) TO SONO RIGANDO NO IGI", STRIDES OF MEDICINE, XX, JP, vol. 173, no. 10, 1 January 1995 (1995-01-01), JP, pages 808 - 812, XP002926108
TAKEJIMA M, NAKAMURA S: "KOUGANZAI YUUHATSUSEI APOTOOSHISU NO TOKUCHOU", STRIDES OF MEDICINE, XX, JP, vol. 173, no. 10, 1 January 1995 (1995-01-01), JP, pages 818 - 823, XP002926109
MOEHRLE H, SCHALTENBRAND R: "AMINOMETHYLIERUNG VON 1,3-DIKETONEN", PHARMAZIE, vol. 40, no. 10, 1 January 1985 (1985-01-01), pages 697 - 701, XP002926107, ISSN: 0031-7144
KASAHARA Y, MIYAWAKI T: "APOTOOSHISU NI OKERU FAS/APO-1 KOUGEN (CD95) TO SONO RIGANDO NO IGI", STRIDES OF MEDICINE, XX, JP, vol. 173, no. 10, 1 January 1995 (1995-01-01), JP, pages 808 - 812, XP002926108
TAKEJIMA M, NAKAMURA S: "KOUGANZAI YUUHATSUSEI APOTOOSHISU NO TOKUCHOU", STRIDES OF MEDICINE, XX, JP, vol. 173, no. 10, 1 January 1995 (1995-01-01), JP, pages 818 - 823, XP002926109
Attorney, Agent or Firm:
Hanabusa, Tsuneo (Kandasurugadai 1-chome Chiyoda-ku Tokyo, JP)
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