APPLICATION OF ABELMOSCHI COROLLA EXTRACT AS TRPC ION CHANNEL INHIBITOR - JIANGSU SUZHONG PHARMACEUTICAL GROUP CO LTD

Title:

APPLICATION OF ABELMOSCHI COROLLA EXTRACT AS TRPC ION CHANNEL INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2021/208984

Kind Code:

A1

Abstract:

An application of an Abelmoschi Corolla extract in preparation of a drug for inhibiting a calcium channel and treating a calcium channel-mediated disease. The disease is a cardiovascular disease, coronary heart disease, atherosclerosis, end-stage renal failure, a neurological disorder, chronic pain, acute pain, or an inflammatory disease. The Abelmoschi Corolla extract contains, by weight, at least one of 0.2% or more of quercetin-3-O-robinoside, 0.5% or more of isoquercitrin, and 0.5% or more of quercetin-3'-O-β-D-glucoside.

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Inventors:

TANG HAITAO (CN)
CAO ZHENGYU (CN)
YU BOYANG (CN)
GE HAITAO (CN)
WANG ZHENGJUN (CN)
MA JIMEI (CN)

Application Number:

PCT/CN2021/087299

Publication Date:

October 21, 2021

Filing Date:

April 14, 2021

Export Citation:

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Assignee:

JIANGSU SUZHONG PHARMACEUTICAL GROUP CO LTD (CN)
NANJING SUZHONG PHARMACEUTICAL RES CO LTD (CN)

International Classes:

A61K36/185; A61K31/192; A61K31/7048; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P29/00

Foreign References:

CN111991408A	2020-11-27
CN111991407A	2020-11-27
CN110075138A	2019-08-02
CN108567802A	2018-09-25

Other References:

LIU LIN, TANG HAI-TAO, LIU HAN-QING, JIN WANG, PING ZHANG, YUN TANG: "Simultaneous Determination of Five Flavonoids and Specific Chromatograms Analysis of HuangKui Capsule", ZHONGYAOCAI - JOURNAL OF CHINESE MEDICINAL MATERIALS, GUOJIA YIYAO GUANLIJU, CN, vol. 36, no. 1, 31 January 2013 (2013-01-31), CN , pages 132 - 136, XP055857881, ISSN: 1001-4454, DOI: 10.13863/j.issn1001-4454.2013.01.040
GAO SHAN, FAN LI DONG LIUYI ZHAO WEIZHONG CHEN ZHIWU: "Effect of TFA on Cell Apoptosis in MCAO Rats", CHINESE PHARMACOLOGICAL BULLETIN, vol. 19, no. 6, 30 June 2003 (2003-06-30), pages 704 - 707, XP055857886

Attorney, Agent or Firm:

JJS INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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