Title:
APPLICATION OF ALBIZIAE CORTEX LIGNAN COMPOUND IN IMPROVING STEATOSIS
Document Type and Number:
WIPO Patent Application WO/2021/063076
Kind Code:
A1
Abstract:
Both of the two Albiziae Cortex lignan compounds provided are chiral compounds, and have the effect of improving lipid metabolism disorders and steatosis. 24 h after administration, when the administration concentration is 5 μM or more, it can effectively treat FFAs-induced lipid metabolism disorders and steatosis. R-type compounds can eliminate the production of reactive oxygen species induced by HG, and after 24 hours of treatment at a dose of 80 μM, the average intensity of intracellular fluorescence is 300.86, which is a significant decrease compared to the fluorescence intensity of the control group of 813.87.
Inventors:
QIU LIYING (CN)
SHI XUELIN (CN)
HOU BAO (CN)
CAI WEIWEI (CN)
LI ZHONGJIE (CN)
LIU YIXIAO (CN)
LI SHUANGSHUANG (CN)
SHI XUELIN (CN)
HOU BAO (CN)
CAI WEIWEI (CN)
LI ZHONGJIE (CN)
LIU YIXIAO (CN)
LI SHUANGSHUANG (CN)
Application Number:
PCT/CN2020/102547
Publication Date:
April 08, 2021
Filing Date:
July 17, 2020
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K31/704; A61K31/7032; A61P1/16; A61P3/00; A61P3/06; A61P3/10
Foreign References:
| CN110585221A | 2019-12-20 | |||
| CN110563781A | 2019-12-13 | |||
| CN110559307A | 2019-12-13 | |||
| CN100574744C | 2009-12-30 | |||
| CN110229202A | 2019-09-13 |
Other References:
SHI, LI, CAI, LIU, AI, SUN, HOU, NI, QIU: "Chemical Constituents from Albiziae Cortex and Their Ability to Ameliorate Steatosis and Promote Proliferation and Anti-oxidation In Vitro", MOLECULES, vol. 24, no. 22, pages 4041, XP055796834, DOI: 10.3390/molecules24224041
WEN QINGWEI: "Study on the Chemical Constituents from Averrhoa Carambola L. Root and Its Hypoglycemic Activities", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES, 9 June 2013 (2013-06-09), XP055796859
JONG-ANURAKKUN, N. BHANDARI, M.R. KAWABATA, J.: "Alpha-Glucosidase inhibitors from Devil tree (Alstonia scholaris)", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 103, no. 4, 27 March 2007 (2007-03-27), NL, pages 1319 - 1323, XP022003135, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2006.10.043
HUANG XUEDAN, XU MINGZHU, SHIRAHATA TATSUYA, LI WEI, KOIKE KAZUO, KOJIMA-YUASA AKIKO, YUASA ISAO, KOBAYASHI YOSHINORI: "Anti-steatosis compounds from leaves of Mallotus furetianus", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, GB, vol. 32, no. 12, 18 June 2018 (2018-06-18), GB, pages 1459 - 1462, XP055796844, ISSN: 1478-6419, DOI: 10.1080/14786419.2017.1350664
WEI, DONGHONG: "Studies on the Active Constituents of Cortex Albizziae", CHINA MASTER’S THESES FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES, no. 04, 15 December 2004 (2004-12-15), pages 1 - 78, XP009527040
SICHAEM JIRAPAST, AREE THAMMARAT, LUGSANANGARM KIATTISAK, TIP-PYANG SANTI: "Identification of highly potent α-glucosidase inhibitory and antioxidant constituents from Zizyphus rugosa bark: enzyme kinetic and molecular docking studies with active metabolites", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, vol. 55, no. 1, 1 January 2017 (2017-01-01), NL, pages 1436 - 1441, XP055796847, ISSN: 1388-0209, DOI: 10.1080/13880209.2017.1304426
WEN QINGWEI: "Study on the Chemical Constituents from Averrhoa Carambola L. Root and Its Hypoglycemic Activities", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE AND HEALTH SCIENCES, 9 June 2013 (2013-06-09), XP055796859
JONG-ANURAKKUN, N. BHANDARI, M.R. KAWABATA, J.: "Alpha-Glucosidase inhibitors from Devil tree (Alstonia scholaris)", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 103, no. 4, 27 March 2007 (2007-03-27), NL, pages 1319 - 1323, XP022003135, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2006.10.043
HUANG XUEDAN, XU MINGZHU, SHIRAHATA TATSUYA, LI WEI, KOIKE KAZUO, KOJIMA-YUASA AKIKO, YUASA ISAO, KOBAYASHI YOSHINORI: "Anti-steatosis compounds from leaves of Mallotus furetianus", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, GB, vol. 32, no. 12, 18 June 2018 (2018-06-18), GB, pages 1459 - 1462, XP055796844, ISSN: 1478-6419, DOI: 10.1080/14786419.2017.1350664
WEI, DONGHONG: "Studies on the Active Constituents of Cortex Albizziae", CHINA MASTER’S THESES FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES, no. 04, 15 December 2004 (2004-12-15), pages 1 - 78, XP009527040
SICHAEM JIRAPAST, AREE THAMMARAT, LUGSANANGARM KIATTISAK, TIP-PYANG SANTI: "Identification of highly potent α-glucosidase inhibitory and antioxidant constituents from Zizyphus rugosa bark: enzyme kinetic and molecular docking studies with active metabolites", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, vol. 55, no. 1, 1 January 2017 (2017-01-01), NL, pages 1436 - 1441, XP055796847, ISSN: 1388-0209, DOI: 10.1080/13880209.2017.1304426
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
Download PDF: