Title:
APPLICATION OF BENFLUMETOL AND DERIVATIVES THEREOF IN TREATMENT OF CORONAVIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO/2022/017431
Kind Code:
A1
Abstract:
The present invention relates to an application of benflumetol and derivatives thereof in treatment of coronavirus infection, and specifically provides a compound represented by formula A, and uses of a stereoisomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof in preparation of drugs. The drugs are used for treating diseases or infection caused by coronavirus (preferably SARS-CoV-2).
Inventors:
CAO RUIYUAN (CN)
WANG MANLI (CN)
LI WEI (CN)
ZHAO LEI (CN)
YANG JINGJING (CN)
LI YUEXIANG (CN)
FAN SHIYONG (CN)
ZHOU XINBO (CN)
XIAO DIAN (CN)
HU ZHIHONG (CN)
LI SONG (CN)
ZHONG WU (CN)
WANG MANLI (CN)
LI WEI (CN)
ZHAO LEI (CN)
YANG JINGJING (CN)
LI YUEXIANG (CN)
FAN SHIYONG (CN)
ZHOU XINBO (CN)
XIAO DIAN (CN)
HU ZHIHONG (CN)
LI SONG (CN)
ZHONG WU (CN)
Application Number:
PCT/CN2021/107739
Publication Date:
January 27, 2022
Filing Date:
July 22, 2021
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
A61K45/06; A61K31/137; A61P31/14
Foreign References:
| CN111686096A | 2020-09-22 | |||
| CN111803491A | 2020-10-23 |
Other References:
CAO RUIYUAN, HU HENGRUI, LI YUFENG, WANG XI, XU MINGYUE, LIU JIA, ZHANG HUANYU, YAN YUNZHENG, ZHAO LEI, LI WEI, ZHANG TIANHONG, XI: "Anti-SARS-CoV-2 Potential of Artemisinins In Vitro", ACS INFECTIOUS DISEASES, vol. 6, no. 9, 11 September 2020 (2020-09-11), US , pages 2524 - 2531, XP055820374, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.0c00522
GENDROT MATHIEU; DUFLOT ISABELLE; BOXBERGER MANON; DELANDRE OCéANE; JARDOT PRISCILLA; LE BIDEAU MARION; ANDREANI JULIEN; FONT: "Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate", INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol. 99, 14 August 2020 (2020-08-14), CA , pages 437 - 440, XP086298675, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2020.08.032
PEELE K. ABRAHAM, POTLA DURTHI CHANDRASAI, SRIHANSA T., KRUPANIDHI S., AYYAGARI VIJAYA SAI, BABU D. JOHN, INDIRA M., REDDY A. RANG: "Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study", INFORMATICS IN MEDICINE UNLOCKED, vol. 19, 1 January 2020 (2020-01-01), pages 100345, XP055889042, ISSN: 2352-9148, DOI: 10.1016/j.imu.2020.100345
UZUN TUĞÇENUR, TOPTAS ORCUN: "Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?", CHINESE MEDICINE, vol. 15, no. 54, 28 May 2020 (2020-05-28), pages 1 - 4, XP055888184, DOI: 10.1186/s13020-020-00336-8
LIU, GUIMEI ET AL.: "Discussion on Artemisinin and Its Derivatives for Treatment of COVID-19", DRUG EVALUATION RESEARCH, vol. 43, no. 4, 30 April 2020 (2020-04-30), pages 606 - 612, XP055888193
SEHAILIA MOUSSA, CHEMAT SMAIN: "Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol. 39, no. 16, 2 November 2021 (2021-11-02), US , pages 6184 - 6194, XP055888187, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1796809
GENDROT MATHIEU; DUFLOT ISABELLE; BOXBERGER MANON; DELANDRE OCéANE; JARDOT PRISCILLA; LE BIDEAU MARION; ANDREANI JULIEN; FONT: "Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate", INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol. 99, 14 August 2020 (2020-08-14), CA , pages 437 - 440, XP086298675, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2020.08.032
PEELE K. ABRAHAM, POTLA DURTHI CHANDRASAI, SRIHANSA T., KRUPANIDHI S., AYYAGARI VIJAYA SAI, BABU D. JOHN, INDIRA M., REDDY A. RANG: "Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study", INFORMATICS IN MEDICINE UNLOCKED, vol. 19, 1 January 2020 (2020-01-01), pages 100345, XP055889042, ISSN: 2352-9148, DOI: 10.1016/j.imu.2020.100345
UZUN TUĞÇENUR, TOPTAS ORCUN: "Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?", CHINESE MEDICINE, vol. 15, no. 54, 28 May 2020 (2020-05-28), pages 1 - 4, XP055888184, DOI: 10.1186/s13020-020-00336-8
LIU, GUIMEI ET AL.: "Discussion on Artemisinin and Its Derivatives for Treatment of COVID-19", DRUG EVALUATION RESEARCH, vol. 43, no. 4, 30 April 2020 (2020-04-30), pages 606 - 612, XP055888193
SEHAILIA MOUSSA, CHEMAT SMAIN: "Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol. 39, no. 16, 2 November 2021 (2021-11-02), US , pages 6184 - 6194, XP055888187, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1796809
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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