Title:
APPLICATION OF COBRA NEUROTOXIN PEPTIDE MOLECULE IN TREATING NEPHRITIS PROTEINURIA
Document Type and Number:
WIPO Patent Application WO/2021/042645
Kind Code:
A1
Abstract:
Provided are applications of a cobra neurotoxin peptide molecule in treating nephritis proteinuria.
Inventors:
QI ZHANKAI (CN)
QI HYATT (CN)
QI HYATT (CN)
Application Number:
PCT/CN2020/000197
Publication Date:
March 11, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
QI ZHANKAI (CN)
International Classes:
A61K38/17; A61P13/12
Foreign References:
| CN110755603A | 2020-02-07 | |||
| CN102846666A | 2013-01-02 | |||
| CN102526695A | 2012-07-04 | |||
| US20090209468A1 | 2009-08-20 | |||
| CN201210228609A | 2012-07-04 |
Other References:
WANG SHUZHI: "Naja Naja Atra Venom And Cobrotoxin Ameliorate Acute And Chronic Nephropathy through Inhibiting Inflammation", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 1 March 2016 (2016-03-01), pages 1 - 83, XP055789634
DATABASE Protein 12 November 2017 (2017-11-12), ANONYMOUS: "RecName: Full=Cobrotoxin; Short=CBT; AltName: Full=Atratoxin; AltName: Full=Short neurotoxin 1; Flags: Precursor", XP055789628, retrieved from Genbank Database accession no. P60770
XU YIN-LI, KOU JIAN-QUN, WANG SHU-ZHI, CHEN CAO-XIN, QIN ZHENG-HONG: "Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 28, no. 1, 1 September 2015 (2015-09-01), pages 188 - 198, XP055789639, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.05.040
ZHANG GUIYUN: "Application of urinary microprotein determination in early diagnosis of nephropathy", CONTEMPORARY MEDICINE, vol. 000, no. 027, 2013, pages 146 - 146
GAO XUEHUI: "Clinical application of urinary microprotein in early renal injury", SHAANXI JLAB SCI, vol. 16, no. 2, May 2001 (2001-05-01)
SONG XUE ET AL.: "Clinical observation and diagnostic value of different urinary proteins in renal diseases", INTERNATIONAL JOURNAL OF UROLOGY, vol. 32, March 2012 (2012-03-01)
ZHU XIAOBIN: "Application value of urine and renal function test in early diagnosis of diabetic nephropathy", CHINESE MEDICAL GUIDELINES
WANG XIAO: "The clinical significance of Urinary Microprotein Detection in the diagnosis of diabetic renal damage", JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 32, no. 6, 2008, pages 751 - 752
SU CAINV ET AL.: "The value of blood and urine microalbuminuria in early diagnosis of diabetic nephropathy", JOURNAL OF RADIOIMMUNOLOGY, vol. 14, no. 4, 2001, pages 502
DUAN LIPING ET AL.: "Analysis of urinary microprotein types and contents in primary nephrotic syndrome and lupus nephropathy", NATIONAL TROPICAL MEDICINE, pages 771 - 772
YANG FANG ET AL.: "Relationship between changes of Urinary Microprotein and renal damage in reflux nephropathy", JOURNAL OF JINAN UNIVERSITY NATURAL SCIENCE AND MEDICINE, no. 004, pages 104 - 106
SHEN SHUNBIAO ET AL.: "Clinical significance of urinary microprotein in IgA nephropathy", CHINESE JOURNAL OF NEPHROLOGY, pages 34 - 34
TENG SHOUFENG ET AL.: "The value of three microalbuminuria in early diagnosis of diabetic renal injury", CHINESE JOURNAL OF MISDIAGNOSIS
SHAO AIHUA ET AL.: "Observation on the results of urinary microprotein in patients with various nephropathy", JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, pages 31 - 32
HUO MEIFENG: "The value of β- 2 microglobulin in the early diagnosis of diabetic nephropathy", CHINESE GENERAL PRACTICE, vol. 12, 2012, pages 119 - 120
KANG PING: "the significance of β- 2 microglobulin in early diabetic nephropathy", HEILONGJIANG MEDICINE, 2008
LU QINGYUN ET AL.: "Clinical significance of a-1x P-2microglobulin in early renal damage of Primary hypertension", WESTERN TRADITIONAL CHINESE MEDICINE, 2014, pages 131 - 133
WANG CHUNWEI: "the clinical value of urine a-1 microglobulin in diabetic nephropathy", JOURNAL OF PRACTICAL MEDICAL TECHNOLOGY
YAN JINGCHUN: "Clinical significance of urine a microglobulin in secondary nephropathy", CHINESE JOURNAL OF COAL INDUSTRY MEDICINE
WEI WENFENG: "The significance of urinary Microtransferrin in the early diagnosis of diabetic nephropathy", LABELED IMMUNOASSAY AND CLINICAL, 2002
LI XIAOXIA ET AL.: "Observation and comparison of urinary transferrin and albumin in early glomerular injury", JOURNAL OF MEDICAL FORUM, 2010
ZHU GUANGBO ET AL.: "Clinical significance of determination of urinary Microtransferrin in patients with diabetes mellitus", SHAANXI MEDICAL JOURNAL, 1999
DONG HUI ET AL.: "The clinical significance of combined detection of microglobulin and transferrin in the early diagnosis of diabetic nephropathy", JOURNAL OF TIANJIN MEDICAL UNIVERSITY, vol. 8, no. 2, 2002, pages 253
MARTIN P ET AL.: "Urinary transferring and early predictor ofglomerular dysfunction", ANNCLIN BIOCHEM, vol. 5, 1988, pages 158
LIU QIAN: "Effect of hemoperfusion combined with continuous blood purification on acute renal failure caused by snake bite", SINO FOREIGN MEDICAL RESEARCH
ZHANG QIONGLIN: "Nursing experience of continuous renal replacement therapy combined with traditional Chinese medicine hoop therapy in the treatment of severe snake bite", FAMILY PSYCHOLOGIST
ZHANG YOUQI ET AL.: "Research Progress on kidney injury caused by snake venom toxin", MEDICAL REVIEW
SHENGWEI XIONGCHUNHONG HUANG: "Synergistic strategies ofpredominant toxins in snake venoms", TOXICOLOGY LETTERS, vol. 287, 2018, pages 142 - 154
LAUSTSEN, A.H.: "Toxin synergism in snake venoms", TOXIN REVIEWS, vol. 35, no. 3-4, pages 165 - 170
ANIL KUMARVARUN GUPTA: "Neurological Implications of Dendrotoxin: AReview", EC PHARMACOLOGY AND TOXICOLOGY, 25 May 2018 (2018-05-25)
STRYDOM DJBOTES DP: "Snake venom toxins-I. Preliminary studies onthe separation of toxins of elapidae venoms", TOXICON, vol. 8, 1970, pages 203 - 9
JOUBERT, F.J.TALJAARD, N: "Snake venoms.The amino-acid sequence ofprotein S2C4 from Dendroaspis jamesoni kaimosae(Jameson's mamba)venom.HoppeSeylers.Z", PHYSIOL.CHEM, vol. 360, 1979, pages 571 - 580
WEINA ET AL.: "Establishment of modified adriamycin nephropathy rat model", JOURNAL OF XI'AN JIAOTONG UNIVERSITY (MEDICAL EDITION, vol. 4, 2009, pages 445 - 452
LI SHIFEN: "Streptozotocin induced diabetic nephropathy in SD rats", CHINESE JOURNAL OF MODERN MEDICINE
ZHOU GUOWU: "a-7 acetylcholine nicotinic receptors regulate inflammation", ADVANCES IN MODERN BIOMEDICINE, 2009
LIU ZHIGANG: "The regulation of a-7 nicotinic acetylcholine receptor and inflammation", CHINA MEDICAL GUIDELINES, 2014
HONG WANG ET AL.: "Nicotinic acetylcholine receptor a7 subunit is an essential regulator of inflammation", NATURE, vol. 421, 23 January 2003 (2003-01-23), XP002277770, DOI: 10.1038/nature01339
STEPHANIE ST-PIERRE ET AL.: "Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival", PLOS ONE, 29 February 2016 (2016-02-29)
See also references of EP 4023242A4
DATABASE Protein 12 November 2017 (2017-11-12), ANONYMOUS: "RecName: Full=Cobrotoxin; Short=CBT; AltName: Full=Atratoxin; AltName: Full=Short neurotoxin 1; Flags: Precursor", XP055789628, retrieved from Genbank Database accession no. P60770
XU YIN-LI, KOU JIAN-QUN, WANG SHU-ZHI, CHEN CAO-XIN, QIN ZHENG-HONG: "Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 28, no. 1, 1 September 2015 (2015-09-01), pages 188 - 198, XP055789639, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.05.040
ZHANG GUIYUN: "Application of urinary microprotein determination in early diagnosis of nephropathy", CONTEMPORARY MEDICINE, vol. 000, no. 027, 2013, pages 146 - 146
GAO XUEHUI: "Clinical application of urinary microprotein in early renal injury", SHAANXI JLAB SCI, vol. 16, no. 2, May 2001 (2001-05-01)
SONG XUE ET AL.: "Clinical observation and diagnostic value of different urinary proteins in renal diseases", INTERNATIONAL JOURNAL OF UROLOGY, vol. 32, March 2012 (2012-03-01)
ZHU XIAOBIN: "Application value of urine and renal function test in early diagnosis of diabetic nephropathy", CHINESE MEDICAL GUIDELINES
WANG XIAO: "The clinical significance of Urinary Microprotein Detection in the diagnosis of diabetic renal damage", JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 32, no. 6, 2008, pages 751 - 752
SU CAINV ET AL.: "The value of blood and urine microalbuminuria in early diagnosis of diabetic nephropathy", JOURNAL OF RADIOIMMUNOLOGY, vol. 14, no. 4, 2001, pages 502
DUAN LIPING ET AL.: "Analysis of urinary microprotein types and contents in primary nephrotic syndrome and lupus nephropathy", NATIONAL TROPICAL MEDICINE, pages 771 - 772
YANG FANG ET AL.: "Relationship between changes of Urinary Microprotein and renal damage in reflux nephropathy", JOURNAL OF JINAN UNIVERSITY NATURAL SCIENCE AND MEDICINE, no. 004, pages 104 - 106
SHEN SHUNBIAO ET AL.: "Clinical significance of urinary microprotein in IgA nephropathy", CHINESE JOURNAL OF NEPHROLOGY, pages 34 - 34
TENG SHOUFENG ET AL.: "The value of three microalbuminuria in early diagnosis of diabetic renal injury", CHINESE JOURNAL OF MISDIAGNOSIS
SHAO AIHUA ET AL.: "Observation on the results of urinary microprotein in patients with various nephropathy", JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, pages 31 - 32
HUO MEIFENG: "The value of β- 2 microglobulin in the early diagnosis of diabetic nephropathy", CHINESE GENERAL PRACTICE, vol. 12, 2012, pages 119 - 120
KANG PING: "the significance of β- 2 microglobulin in early diabetic nephropathy", HEILONGJIANG MEDICINE, 2008
LU QINGYUN ET AL.: "Clinical significance of a-1x P-2microglobulin in early renal damage of Primary hypertension", WESTERN TRADITIONAL CHINESE MEDICINE, 2014, pages 131 - 133
WANG CHUNWEI: "the clinical value of urine a-1 microglobulin in diabetic nephropathy", JOURNAL OF PRACTICAL MEDICAL TECHNOLOGY
YAN JINGCHUN: "Clinical significance of urine a microglobulin in secondary nephropathy", CHINESE JOURNAL OF COAL INDUSTRY MEDICINE
WEI WENFENG: "The significance of urinary Microtransferrin in the early diagnosis of diabetic nephropathy", LABELED IMMUNOASSAY AND CLINICAL, 2002
LI XIAOXIA ET AL.: "Observation and comparison of urinary transferrin and albumin in early glomerular injury", JOURNAL OF MEDICAL FORUM, 2010
ZHU GUANGBO ET AL.: "Clinical significance of determination of urinary Microtransferrin in patients with diabetes mellitus", SHAANXI MEDICAL JOURNAL, 1999
DONG HUI ET AL.: "The clinical significance of combined detection of microglobulin and transferrin in the early diagnosis of diabetic nephropathy", JOURNAL OF TIANJIN MEDICAL UNIVERSITY, vol. 8, no. 2, 2002, pages 253
MARTIN P ET AL.: "Urinary transferring and early predictor ofglomerular dysfunction", ANNCLIN BIOCHEM, vol. 5, 1988, pages 158
LIU QIAN: "Effect of hemoperfusion combined with continuous blood purification on acute renal failure caused by snake bite", SINO FOREIGN MEDICAL RESEARCH
ZHANG QIONGLIN: "Nursing experience of continuous renal replacement therapy combined with traditional Chinese medicine hoop therapy in the treatment of severe snake bite", FAMILY PSYCHOLOGIST
ZHANG YOUQI ET AL.: "Research Progress on kidney injury caused by snake venom toxin", MEDICAL REVIEW
SHENGWEI XIONGCHUNHONG HUANG: "Synergistic strategies ofpredominant toxins in snake venoms", TOXICOLOGY LETTERS, vol. 287, 2018, pages 142 - 154
LAUSTSEN, A.H.: "Toxin synergism in snake venoms", TOXIN REVIEWS, vol. 35, no. 3-4, pages 165 - 170
ANIL KUMARVARUN GUPTA: "Neurological Implications of Dendrotoxin: AReview", EC PHARMACOLOGY AND TOXICOLOGY, 25 May 2018 (2018-05-25)
STRYDOM DJBOTES DP: "Snake venom toxins-I. Preliminary studies onthe separation of toxins of elapidae venoms", TOXICON, vol. 8, 1970, pages 203 - 9
JOUBERT, F.J.TALJAARD, N: "Snake venoms.The amino-acid sequence ofprotein S2C4 from Dendroaspis jamesoni kaimosae(Jameson's mamba)venom.HoppeSeylers.Z", PHYSIOL.CHEM, vol. 360, 1979, pages 571 - 580
WEINA ET AL.: "Establishment of modified adriamycin nephropathy rat model", JOURNAL OF XI'AN JIAOTONG UNIVERSITY (MEDICAL EDITION, vol. 4, 2009, pages 445 - 452
LI SHIFEN: "Streptozotocin induced diabetic nephropathy in SD rats", CHINESE JOURNAL OF MODERN MEDICINE
ZHOU GUOWU: "a-7 acetylcholine nicotinic receptors regulate inflammation", ADVANCES IN MODERN BIOMEDICINE, 2009
LIU ZHIGANG: "The regulation of a-7 nicotinic acetylcholine receptor and inflammation", CHINA MEDICAL GUIDELINES, 2014
HONG WANG ET AL.: "Nicotinic acetylcholine receptor a7 subunit is an essential regulator of inflammation", NATURE, vol. 421, 23 January 2003 (2003-01-23), XP002277770, DOI: 10.1038/nature01339
STEPHANIE ST-PIERRE ET AL.: "Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival", PLOS ONE, 29 February 2016 (2016-02-29)
See also references of EP 4023242A4
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