Title:
APPLICATION OF HYDRAZIDE COMPOUND IN TUMOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/025011
Kind Code:
A1
Abstract:
The present invention relates to an application of a hydrazide compound in tumor treatment, and, in particular, the present invention provides a use of a compound represented by formula I, an optical isomer or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, being used for the preparation of a composition or formulation, said composition or formulation being used for the prevention and/or treatment of tumors. The compound of the present invention has significant and exceptional therapeutic effects on tumors having low or no expression of the NNMT gene, high expression of DNA methylase, high expression of UHRF1, high methylation level at the NNMT gene nucleotide site, and/or high methylation level at a DNA CpG site in the NNMT gene region.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
MA WENJIANG (CN)
Application Number:
PCT/CN2022/113195
Publication Date:
March 02, 2023
Filing Date:
August 18, 2022
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
International Classes:
A61K31/345; A61K31/422; A61P35/00; C12N15/11; C12Q1/6886; G01N33/574
Foreign References:
| CN109793729A | 2019-05-24 | |||
| CN101500557A | 2009-08-05 | |||
| CN103025890A | 2013-04-03 | |||
| CN111653315A | 2020-09-11 | |||
| CN112094909A | 2020-12-18 | |||
| CN112941184A | 2021-06-11 | |||
| CN112494467A | 2021-03-16 |
Other References:
RIVAS MARIA PRATES, AGUIAR TALITA FERREIRA MARQUES, MASCHIETTO MARIANA, LEMES RENAN B, CAIRES-JÚNIOR LUIZ CARLOS, GOULART ERNESTO,: "Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 42, no. 12, 1 December 2020 (2020-12-01), CH , pages 101042832097712, XP093037412, ISSN: 1010-4283, DOI: 10.1177/1010428320977124
Attorney, Agent or Firm:
PANCHINA IP LAW OFFICE (CN)
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