Title:
APPLICATION OF ICETEXANE-TYPE ABIETANE DITERPENE IN PREPARATION OF DRUG FOR TREATING COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2022/142160
Kind Code:
A1
Abstract:
Disclosed in the present invention is an application of Icetexane-type abietane diterpene in preparation of a drug for treating colorectal cancer. The mechanism of action is that a binding immunoglobulin protein (BiP) level in the endoplasmic reticulum is up-regulated, so that the transfer of the BiP protein from the cytoplasm to the cell nucleus is promoted, thereby inducing apoptosis. The present invention further expands the application range of the Icetexane-type abietane diterpene and derivatives thereof.
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Inventors:
DENG XU (CN)
ZHOU YINGJUN (CN)
CAO WEI (CN)
LIU TINGTING (CN)
YANG SHUTING (CN)
ZENG GUANGYAO (CN)
ZHOU YINGJUN (CN)
CAO WEI (CN)
LIU TINGTING (CN)
YANG SHUTING (CN)
ZENG GUANGYAO (CN)
Application Number:
PCT/CN2021/099949
Publication Date:
July 07, 2022
Filing Date:
June 15, 2021
Export Citation:
Assignee:
UNIV CENTRAL SOUTH (CN)
International Classes:
A61K31/192; A61K31/05; A61K31/122; A61K31/336; A61K31/343; A61K31/357; A61P35/04
Foreign References:
| CN112618530A | 2021-04-09 |
Other References:
NAIDU, V.G.M. ET AL.: "Antioxidant, hepatoprotective and cytotoxic effects of icetexanes isolated from stem-bark of Premna tomentosa", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, 1 April 2014 (2014-04-01), AMSTERDAM, NL , pages 497 - 505, XP018519045, ISSN: 0944-7113
MAJETICH GEORGE, ZOU GE: "Total Synthesis of (−)-Barbatusol, (+)-Demethylsalvicanol, (−)-Brussonol, and (+)-Grandione", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 1, 1 January 2008 (2008-01-01), US , pages 81 - 83, XP055949027, ISSN: 1523-7060, DOI: 10.1021/ol701800d
PAN ZHENG-HONG, XU GANG, ZHAO QIN-SHI: "Advances in rearch on diterpenoid constituents of Salvia species", GUIHAIA, vol. 30, no. 6, 15 November 2010 (2010-11-15), pages 791 - 7990, XP055950757, ISSN: 1000-3142
KELECOM ALPHONSE, WALTER L.B. MEDEIROS: "A NOVEL REARRANGED ABIETANE DITERPENE FROM Coleus barbatus.", BULLETIN DES SOCIéTéS CHIMIQUES BELGES : VLAAMSE CHEMISCHE VERENIGING, CENTERICK, BE, vol. 98, no. 6, 1 June 1989 (1989-06-01), BE , pages 413 - 414, XP055950734, ISSN: 0037-9646, DOI: 10.1002/bscb.19890980609
MOUJIR LAILA, ANGEL M. GUTIÉRREZ-NAVARRO,LUCIA SAN ANDRÉS,JAVIER G. LUIS: "Bioactive Diterpenoids Isolated from Salvia mellifera.", PHYSIOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER., GB, vol. 10, no. 02, 1 March 1996 (1996-03-01), GB , pages 172 - 174, XP055950736, ISSN: 0951-418X
AOYAGI YUTAKA, YOSHINAO TAKAHASHI, HARUHIKO FUKAYA, KOICHI TAKEYA, RITSUO AIYAMA, TAKESHI MATSUZAKI, SHUSUKE HASHIMOTO, TERUO KURI: "Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity.", CHEMICAL AND PHARMACEUTICAL BULLETIN, JP, vol. 54, no. 11, 1 November 2006 (2006-11-01), JP , pages 1602 - 1604, XP055950738, ISSN: 1347-5223, DOI: 10.1248/cpb.54.1602
AOYAGI, Y. ; TAKAHASHI, Y. ; SATAKE, Y. ; FUKAYA, H. ; TAKEYA, K. ; AIYAMA, R. ; MATSUZAKI, T. ; HASHIMOTO, S. ; SHIINA, T. ; KURI: "Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels-Alder type dimerization and structure revision of grandione", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 46, no. 46, 14 November 2005 (2005-11-14), Amsterdam , NL , pages 7885 - 7887, XP027863590, ISSN: 0040-4039
MAJETICH GEORGE, ZOU GE: "Total Synthesis of (−)-Barbatusol, (+)-Demethylsalvicanol, (−)-Brussonol, and (+)-Grandione", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 1, 1 January 2008 (2008-01-01), US , pages 81 - 83, XP055949027, ISSN: 1523-7060, DOI: 10.1021/ol701800d
PAN ZHENG-HONG, XU GANG, ZHAO QIN-SHI: "Advances in rearch on diterpenoid constituents of Salvia species", GUIHAIA, vol. 30, no. 6, 15 November 2010 (2010-11-15), pages 791 - 7990, XP055950757, ISSN: 1000-3142
KELECOM ALPHONSE, WALTER L.B. MEDEIROS: "A NOVEL REARRANGED ABIETANE DITERPENE FROM Coleus barbatus.", BULLETIN DES SOCIéTéS CHIMIQUES BELGES : VLAAMSE CHEMISCHE VERENIGING, CENTERICK, BE, vol. 98, no. 6, 1 June 1989 (1989-06-01), BE , pages 413 - 414, XP055950734, ISSN: 0037-9646, DOI: 10.1002/bscb.19890980609
MOUJIR LAILA, ANGEL M. GUTIÉRREZ-NAVARRO,LUCIA SAN ANDRÉS,JAVIER G. LUIS: "Bioactive Diterpenoids Isolated from Salvia mellifera.", PHYSIOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER., GB, vol. 10, no. 02, 1 March 1996 (1996-03-01), GB , pages 172 - 174, XP055950736, ISSN: 0951-418X
AOYAGI YUTAKA, YOSHINAO TAKAHASHI, HARUHIKO FUKAYA, KOICHI TAKEYA, RITSUO AIYAMA, TAKESHI MATSUZAKI, SHUSUKE HASHIMOTO, TERUO KURI: "Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity.", CHEMICAL AND PHARMACEUTICAL BULLETIN, JP, vol. 54, no. 11, 1 November 2006 (2006-11-01), JP , pages 1602 - 1604, XP055950738, ISSN: 1347-5223, DOI: 10.1248/cpb.54.1602
AOYAGI, Y. ; TAKAHASHI, Y. ; SATAKE, Y. ; FUKAYA, H. ; TAKEYA, K. ; AIYAMA, R. ; MATSUZAKI, T. ; HASHIMOTO, S. ; SHIINA, T. ; KURI: "Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels-Alder type dimerization and structure revision of grandione", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 46, no. 46, 14 November 2005 (2005-11-14), Amsterdam , NL , pages 7885 - 7887, XP027863590, ISSN: 0040-4039
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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