APPLICATION OF ICOS+CXCR3+ REGULATORY T CELLS IN PREPARATION OF MEDICINE FOR PREVENTING SEVERE PNEUMONIA

Title:

APPLICATION OF ICOS+CXCR3+ REGULATORY T CELLS IN PREPARATION OF MEDICINE FOR PREVENTING SEVERE PNEUMONIA

Document Type and Number:

WIPO Patent Application WO/2021/047144

Kind Code:

A1

Abstract:

Provided are application of ICOS+CXCR3+ regulatory T cells in preparation of a medicine for preventing severe pneumonia, and the medicine for preventing pneumonia. The medicine comprises the ICOS+CXCR3+ regulatory T cells and a pharmaceutically acceptable carrier.

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Inventors:

SUN LINGYUN (CN)
LI WENCHAO (CN)
CHEN WEIWEI (CN)

Application Number:

PCT/CN2020/073987

Publication Date:

March 18, 2021

Filing Date:

January 23, 2020

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Assignee:

NANJING DRUM TOWER HOSPITAL (CN)

International Classes:

C12N5/0783; A61K35/17; A61P11/00

Domestic Patent References:

WO2018025221A1	2018-02-08
WO2013096732A2	2013-06-27

Foreign References:

CN107617105A

2018-01-23

Other References:

BENTEBIBEL S.-E., LOPEZ S., OBERMOSER G., SCHMITT N., MUELLER C., HARROD C., FLANO E., MEJIAS A., ALBRECHT R. A., BLANKENSHIP D., : "Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 176, 13 March 2013 (2013-03-13), pages 1 - 16, XP055791579, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3005191
PRIYA SAKTHIVEL; GEREKE MARCUS; BREITHAUPT ANGELE; FUCHS DIETMAR; GIGLIOTTI LUCA; GRUBER ACHIM; DIANZANI UMBERTO; BRUDER DUNJA; GU: "Attenuation of Immune-Mediated Influenza Pneumonia by Targeting the Inducible Co-Stimulator (ICOS) Molecule on T Cells", PLOS ONE, vol. 9, no. 7, 16 July 2017 (2017-07-16), pages 1 - 11, XP055255507, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0100970

Attorney, Agent or Firm:

NANJING ZHONGSHAN PATENT AGENT CO., LTD. (CN)

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