Title:
APPLICATION OF N-BUTYLLITHIUM IN CATALYZING HYDROBORATION OF CARBONYL COMPOUND AND BORANE
Document Type and Number:
WIPO Patent Application WO/2019/200520
Kind Code:
A1
Abstract:
Disclosed is an application of n-butyllithium in catalyzing hydroboration of a carbonyl compound and borane. In an anhydrous oxygen-free environment, borane is added in an inert gas atmosphere to a reaction flask having been subjected to dehydration and deoxidation treatment, then a catalyst n-butyllithium is added and uniformly mixed, and a carbonyl compound is further added to carry out a reaction. Subsequently, the reaction is terminated by exposure to air to obtain a borate. The n-butyllithium has high catalytic activity in the hydroboration of the carbonyl compound and borane with mild reaction conditions and a short reaction time, thereby reducing environmental pollution. The catalyst is effective for aromatic aldehydes (ketones) having different substitution positions and different electronic effects and for heterocyclic aldehydes (ketones), and is widely applicable to fatty aldehydes (ketones), thereby providing more choices for obtaining borate compounds with different substituent structures.
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Inventors:
XUE MINGQIANG (CN)
ZHU ZHANGYE (CN)
XU XIAOJUAN (CN)
WU ZHENJIE (CN)
HONG YUBIAO (CN)
SHEN QI (CN)
ZHU ZHANGYE (CN)
XU XIAOJUAN (CN)
WU ZHENJIE (CN)
HONG YUBIAO (CN)
SHEN QI (CN)
Application Number:
PCT/CN2018/083248
Publication Date:
October 24, 2019
Filing Date:
April 17, 2018
Export Citation:
Assignee:
NANTONG TEXTILE & SILK INDUSTRIAL TECH RESEARCH INSTITUTE (CN)
UNIV SOOCHOW (CN)
UNIV SOOCHOW (CN)
International Classes:
B01J31/12; C07F5/04
Domestic Patent References:
| WO2013080583A1 | 2013-06-06 |
Foreign References:
| CN108404984A | 2018-08-17 | |||
| CN108654692A | 2018-10-16 | |||
| CN106749372A | 2017-05-31 | |||
| CN103012455A | 2013-04-03 | |||
| EP1562961A1 | 2005-08-17 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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