Title:
APPLICATION OF NANOBODY TARGETING ON IL-6Rα
Document Type and Number:
WIPO Patent Application WO/2024/093652
Kind Code:
A1
Abstract:
The present invention discloses a nanobody targeting IL-6Rα protein and uses thereof, wherein the heavy chain variable region of the nanobody comprises three complementary determining regions, CDR1, CDR2, and CDR3, wherein CDR1 has an amino acid sequence as shown in SEQ ID NO. 2, CDR2 has an amino acid sequence as shown in SEQ ID NO. 3, and CDR3 has an amino acid sequence as shown in SEQ ID NO. 4. With high affinity to IL-6Rα protein and high stability and water solubility, the nanobody can be used in the development of pharmaceutical compositions for the treatment of IL-6-mediated related diseases or conditions, as well as in the development of reagents or kits for the detection of IL-6Rα, which can provide potentially highly effective antibodies for the study of IL-6-mediated related diseases, and provide new therapeutic strategies and targets for autoimmune diseases or tumors.
Inventors:
LI BOFENG (CN)
JIN TENGCHUAN (CN)
QIAN JIAOJIAO (CN)
JIN TENGCHUAN (CN)
QIAN JIAOJIAO (CN)
Application Number:
PCT/CN2023/124570
Publication Date:
May 10, 2024
Filing Date:
October 13, 2023
Export Citation:
Assignee:
INSTITUTE OF HEALTH AND MEDICINE HEFEI COMPREHENSIVE NAT SCIENCE CENTER (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12N15/85
Domestic Patent References:
| WO2008071685A1 | 2008-06-19 |
Foreign References:
| CN112778416A | 2021-05-11 | |||
| CN110903393A | 2020-03-24 | |||
| RU2603269C1 | 2016-11-27 | |||
| CN105399828A | 2016-03-16 | |||
| CN101528778A | 2009-09-09 |
Other References:
DONNA K. FINCH; MATTHEW A. SLEEMAN; JACQUES MOISAN; FRANCO FERRARO; SARA BOTTERELL; JAMIE CAMPBELL; DUNCAN COCHRANE; SIMON CRUWYS;: "Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 411, no. 4, 16 June 2011 (2011-06-16), United Kingdom , pages 791 - 807, XP028259790, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2011.06.031
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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