Title:
APPLICATION OF NON-IGF1R-BINDING SUBSTANCE IN PREVENTION AND/OR TREATMENT OF INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/047607
Kind Code:
A1
Abstract:
Provided is an application of a non-IGF1R-binding substance in the prevention and/or treatment of inflammatory diseases. Specifically, provided is use of a non-IGF1R-binding substance. The non-IGF1R-binding substance is used for preparing a composition or formulation, and the composition or formulation is used for preventing and/or treating inflammatory diseases.
Inventors:
SHI YUFANG (CN)
WANG YING (CN)
WANG XUEFENG (CN)
WANG YING (CN)
WANG XUEFENG (CN)
Application Number:
PCT/CN2020/114587
Publication Date:
March 18, 2021
Filing Date:
September 10, 2020
Export Citation:
Assignee:
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K45/00; A61K38/18; A61K38/30; A61P29/00; A61P37/02
Domestic Patent References:
| WO2018099363A1 | 2018-06-07 | |||
| WO2011098400A1 | 2011-08-18 |
Foreign References:
| CN106167789A | 2016-11-30 | |||
| US20090275608A1 | 2009-11-05 | |||
| CN107582566A | 2018-01-16 | |||
| CN109053875A | 2018-12-21 |
Other References:
DU LIMING, LIN LIANGYU, LI QING, LIU KELI, HUANG YIN, WANG XUEFENG, CAO KAI, CHEN XIAODONG, CAO WEI, LI FENGYING, SHAO CHANGSHUN, : "IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties", CELL METABOLISM, CELL PRESS, UNITED STATES, vol. 29, no. 6, 1 June 2019 (2019-06-01), United States, pages 1363 - 1375.e8, XP055790728, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.01.006
ROTH, B.V. ; BURGISSER, D.M. ; LUTHI, C. ; HUMBEL, R.E.: "Mutants of human insulin-like growth factor II: Expression and characterization of analogs with a substitution of Tyr^2^7 and/or a deletion of residues 62-67", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 16 December 1991 (1991-12-16), Amsterdam NL, pages 907 - 914, XP024840430, ISSN: 0006-291X, DOI: 10.1016/0006-291X(91)91277-J
MARGOT W BEUKERS, YOUNGMAN OH, HEPING ZHANG, NICHOLAS LING, RON G ROSENFELD: "[Leu27] INSULIN-LIKE GROWTH FACTOR II IS HIGHLY SELECTIVE FOR THE TYPE-II IGF RECEPTOR IN BINDING, CROSS-LINKING AND THYMIDINE INCORPORATION EXPERIMENTS", ENDOCRINOLOGY, vol. 128, no. 2, 1 February 1991 (1991-02-01), US , pages 1201 - 1203, XP009535048, ISSN: 0013-7227, DOI: 10.1210/endo-128-2-1201
WANG, ZHONGYAN : "Research Advances in Insulin-like Growth Factor", LIVESTOCK AND POULTRY INDUSTRY, no. 11, 31 December 2004 (2004-12-31), CN, pages 62 - 64, XP009535440, ISSN: 1008-0414, DOI: 10.19567/j.cnki.1008-0414.2004.11.040
YU, HROHAN, T: "Role of the insulin-like growth factor family in cancer development and progression", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 92, 2000, pages 1472 - 1489, XP002414394, DOI: 10.1093/jnci/92.18.1472
ENGUITA-GERMAN, MFORTES, P: "Targeting the insulin-like growth factor pathway in hepatocellular carcinoma", WORLD JOURNAL OF HEPATOLOGY, vol. 6, 2014, pages 716 - 737
KILLIAN, J. K.JIRTLE, R. L.: "Genomic structure of the human M6P/IGF2 receptor", MAMMALIAN GENOME : OFFICIAL JOURNAL OF THE INTERNATIONAL MAMMALIAN GENOME SOCIETY, vol. 10, 1999, pages 74 - 77
GARY-BOBO, M.NIRDE, P.JEANJEAN, A.MORERE, AGARCIA, M: "Mannose 6-phosphate receptor targeting and its applications in human diseases", CURRENT MEDICINAL CHEMISTRY, vol. 14, 2007, pages 2945 - 2953, XP002557212, DOI: 10.2174/092986707782794005
COSTELLO, M.BAXTER, R. C.SCOTT, C. D.: "Regulation of soluble insulin-like growth factor II/mannose 6-phosphate receptor in human serum: measurement by enzyme-linked immunosorbent assay", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 84, 1999, pages 611 - 617
SHEET, A: "d. f.", 2016, DEPARTMENT OF HEALTH AND HUMAN SERVICES
BORGELT, L. M.: "Immunity and autoimmune diseases", WOMEN'S HEALTH ACROSS THE LIFESPAN: A PHARMACOTHERAPEUTIC APPROACH, 2010
HANAYAMA RT. M.MIWA KSHINOHARA AIWAMATSU ANAGATA S: "Identification of a factor that links apoptotic cells to phagocytes", NATURE, vol. 417, no. 6885, 2002, pages 182 - 7, XP002965210, DOI: 10.1038/417182a
MIKSA, M.AMIN, D.WU, R.RAVIKUMAR, T. S.WANG, P: "Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages", MOLECULAR MEDICINE, vol. 13, pages 553 - 560
MIKSA, M ET AL.: "Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 22, 2008, pages 743 - 748
FERRERO-MILIANI, L.NIELSEN, O. H.ANDERSEN, P. S.GIRARDIN, S. E.: "Chronic inflammation: importance of NOD2 and NALP3 in interleukin-lbeta generation", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 147, 2007, pages 227 - 235
A.H.A. A. B. L.: "Basic Immunology. Functions and disorders of the immune system", 2009, ELSEVIER, article "Ch.2 Innate Immunity"
HOCKING, P. M.ROBERTSON, G. W.GENTLE, M. J.: "Effects of anti-inflammatory steroid drugs on pain coping behaviours in a model of articular pain in the domestic fowl", RESEARCH IN VETERINARY SCIENCE, vol. 71, 2001, pages 161 - 166
MENKES, C. J.: "Effects of disease-modifying anti-rheumatic drugs, steroids and non-steroidal anti-inflammatory drugs on acute-phase proteins in rheumatoid arthritis", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 3, 1993, pages 14 - 18
OHUCHI, S. T. S. S.: "Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment", vol. 4, 1980, WILLOUGHBY D.A., article "A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs"
WARDEN, S. J.: "Prophylactic use of NSAIDs by athletes: a risk/benefit assessment", THE PHYSICIAN AND SPORTSMEDICINE, vol. 38, 2010, pages 132 - 138
KUMEJI TAKEUCHI, N. I.NOBORU HASEGAWAYOKO YOSHIDAKENJI YAMADAHIROSHI KOGOYOSHIO AIZAWA: "Inhibitory action of non-steroidal anti-inflammatory drugs on prostaglandin synthesis and release", FOLIA PHARMACOLOGICA JAPONICA, vol. 76, 1980, pages 525 - 531
CLAUSEN, B. E.BURKHARDT, C.REITH, W.RENKAWITZ, RFORSTER, I: "Conditional gene targeting in macrophages and granulocytes using LysMcre mice", TRANSGENIC RESEARCH, 1999
ZIGMOND, E ET AL.: "Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells", IMMUNITY, vol. 37, 2012, pages 1076 - 1090
CHASSAING, B.AITKEN, J. D.MALLESHAPPA, MVIJAY-KUMAR, M: "Dextran sulfate sodium (DSS)-induced colitis in mice", CURRENT PROTOCOLS IN IMMUNOLOGY, vol. 104, 2014, XP055723883, DOI: 10.1002/0471142735.im1525s104
See also references of EP 4046658A4
ROTH, B.V. ; BURGISSER, D.M. ; LUTHI, C. ; HUMBEL, R.E.: "Mutants of human insulin-like growth factor II: Expression and characterization of analogs with a substitution of Tyr^2^7 and/or a deletion of residues 62-67", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 16 December 1991 (1991-12-16), Amsterdam NL, pages 907 - 914, XP024840430, ISSN: 0006-291X, DOI: 10.1016/0006-291X(91)91277-J
MARGOT W BEUKERS, YOUNGMAN OH, HEPING ZHANG, NICHOLAS LING, RON G ROSENFELD: "[Leu27] INSULIN-LIKE GROWTH FACTOR II IS HIGHLY SELECTIVE FOR THE TYPE-II IGF RECEPTOR IN BINDING, CROSS-LINKING AND THYMIDINE INCORPORATION EXPERIMENTS", ENDOCRINOLOGY, vol. 128, no. 2, 1 February 1991 (1991-02-01), US , pages 1201 - 1203, XP009535048, ISSN: 0013-7227, DOI: 10.1210/endo-128-2-1201
WANG, ZHONGYAN : "Research Advances in Insulin-like Growth Factor", LIVESTOCK AND POULTRY INDUSTRY, no. 11, 31 December 2004 (2004-12-31), CN, pages 62 - 64, XP009535440, ISSN: 1008-0414, DOI: 10.19567/j.cnki.1008-0414.2004.11.040
YU, HROHAN, T: "Role of the insulin-like growth factor family in cancer development and progression", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 92, 2000, pages 1472 - 1489, XP002414394, DOI: 10.1093/jnci/92.18.1472
ENGUITA-GERMAN, MFORTES, P: "Targeting the insulin-like growth factor pathway in hepatocellular carcinoma", WORLD JOURNAL OF HEPATOLOGY, vol. 6, 2014, pages 716 - 737
KILLIAN, J. K.JIRTLE, R. L.: "Genomic structure of the human M6P/IGF2 receptor", MAMMALIAN GENOME : OFFICIAL JOURNAL OF THE INTERNATIONAL MAMMALIAN GENOME SOCIETY, vol. 10, 1999, pages 74 - 77
GARY-BOBO, M.NIRDE, P.JEANJEAN, A.MORERE, AGARCIA, M: "Mannose 6-phosphate receptor targeting and its applications in human diseases", CURRENT MEDICINAL CHEMISTRY, vol. 14, 2007, pages 2945 - 2953, XP002557212, DOI: 10.2174/092986707782794005
COSTELLO, M.BAXTER, R. C.SCOTT, C. D.: "Regulation of soluble insulin-like growth factor II/mannose 6-phosphate receptor in human serum: measurement by enzyme-linked immunosorbent assay", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 84, 1999, pages 611 - 617
SHEET, A: "d. f.", 2016, DEPARTMENT OF HEALTH AND HUMAN SERVICES
BORGELT, L. M.: "Immunity and autoimmune diseases", WOMEN'S HEALTH ACROSS THE LIFESPAN: A PHARMACOTHERAPEUTIC APPROACH, 2010
HANAYAMA RT. M.MIWA KSHINOHARA AIWAMATSU ANAGATA S: "Identification of a factor that links apoptotic cells to phagocytes", NATURE, vol. 417, no. 6885, 2002, pages 182 - 7, XP002965210, DOI: 10.1038/417182a
MIKSA, M.AMIN, D.WU, R.RAVIKUMAR, T. S.WANG, P: "Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages", MOLECULAR MEDICINE, vol. 13, pages 553 - 560
MIKSA, M ET AL.: "Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 22, 2008, pages 743 - 748
FERRERO-MILIANI, L.NIELSEN, O. H.ANDERSEN, P. S.GIRARDIN, S. E.: "Chronic inflammation: importance of NOD2 and NALP3 in interleukin-lbeta generation", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 147, 2007, pages 227 - 235
A.H.A. A. B. L.: "Basic Immunology. Functions and disorders of the immune system", 2009, ELSEVIER, article "Ch.2 Innate Immunity"
HOCKING, P. M.ROBERTSON, G. W.GENTLE, M. J.: "Effects of anti-inflammatory steroid drugs on pain coping behaviours in a model of articular pain in the domestic fowl", RESEARCH IN VETERINARY SCIENCE, vol. 71, 2001, pages 161 - 166
MENKES, C. J.: "Effects of disease-modifying anti-rheumatic drugs, steroids and non-steroidal anti-inflammatory drugs on acute-phase proteins in rheumatoid arthritis", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 3, 1993, pages 14 - 18
OHUCHI, S. T. S. S.: "Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment", vol. 4, 1980, WILLOUGHBY D.A., article "A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs"
WARDEN, S. J.: "Prophylactic use of NSAIDs by athletes: a risk/benefit assessment", THE PHYSICIAN AND SPORTSMEDICINE, vol. 38, 2010, pages 132 - 138
KUMEJI TAKEUCHI, N. I.NOBORU HASEGAWAYOKO YOSHIDAKENJI YAMADAHIROSHI KOGOYOSHIO AIZAWA: "Inhibitory action of non-steroidal anti-inflammatory drugs on prostaglandin synthesis and release", FOLIA PHARMACOLOGICA JAPONICA, vol. 76, 1980, pages 525 - 531
CLAUSEN, B. E.BURKHARDT, C.REITH, W.RENKAWITZ, RFORSTER, I: "Conditional gene targeting in macrophages and granulocytes using LysMcre mice", TRANSGENIC RESEARCH, 1999
ZIGMOND, E ET AL.: "Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells", IMMUNITY, vol. 37, 2012, pages 1076 - 1090
CHASSAING, B.AITKEN, J. D.MALLESHAPPA, MVIJAY-KUMAR, M: "Dextran sulfate sodium (DSS)-induced colitis in mice", CURRENT PROTOCOLS IN IMMUNOLOGY, vol. 104, 2014, XP055723883, DOI: 10.1002/0471142735.im1525s104
See also references of EP 4046658A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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