Title:
APPLICATION OF PDE3 INHIBITOR AND CYTOKINE IN TREATMENT OF TUMOR
Document Type and Number:
WIPO Patent Application WO/2021/036937
Kind Code:
A1
Abstract:
Provided are an application of a PDE3 inhibitor and a cytokine in the treatment of a tumor, and a pharmaceutical composition, said composition comprising: (a) a therapeutically effective dose of a first active ingredient, said first active ingredient being a PDE3 inhibitor; and (b) a therapeutically effective dose of a second active ingredient, said second active ingredient being a cytokine. The combined application of PDE3 inhibitor and cytokine has an obvious synergistic anti-cancer effect.
Inventors:
YU QIANG (CN)
AN RAN (CN)
AN RAN (CN)
Application Number:
PCT/CN2020/110552
Publication Date:
March 04, 2021
Filing Date:
August 21, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/517; A61K31/50; A61K38/19; A61K38/21; A61P35/00
Foreign References:
| CN1720226A | 2006-01-11 | |||
| CN108366947A | 2018-08-03 | |||
| EP2915526A1 | 2015-09-09 |
Other References:
PULKKA OLLI-PEKKA, GEBREYOHANNES YEMARSHET K., WOZNIAK AGNIESZKA, MPINDI JOHN-PATRICK, TYNNINEN OLLI, ICAY KATHERINE, CERVERA ALEJ: "Anagrelide for Gastrointestinal Stromal Tumor", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 25, no. 5, 1 March 2019 (2019-03-01), US, pages 1676 - 1687, XP055785487, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-18-0815
ESSAYAN D. M., ET AL.: "EFFECTS ON NONSELECTIVE AND ISOZYME SELECTIVE CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS ON ANTIGE-INDUCED CYTOKINE GENE EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS.", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 13., 1 January 1995 (1995-01-01), NEW YORK, NY, US, pages 692 - 702., XP000576387, ISSN: 1044-1549
SEYBOLD JOACHIM, THOMAS DIRK, WITZENRATH MARTIN, BORAL ŞENGÜL, HOCKE ANDREAS C., BÜRGER ALEXANDER, HATZELMANN ARMIN, TENOR HERM: "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 105, no. 9, 1 May 2005 (2005-05-01), US, pages 3569 - 3576, XP055785495, ISSN: 0006-4971, DOI: 10.1182/blood-2004-07-2729
ESSAYAN D. M., ET AL.: "EFFECTS ON NONSELECTIVE AND ISOZYME SELECTIVE CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS ON ANTIGE-INDUCED CYTOKINE GENE EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS.", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 13., 1 January 1995 (1995-01-01), NEW YORK, NY, US, pages 692 - 702., XP000576387, ISSN: 1044-1549
SEYBOLD JOACHIM, THOMAS DIRK, WITZENRATH MARTIN, BORAL ŞENGÜL, HOCKE ANDREAS C., BÜRGER ALEXANDER, HATZELMANN ARMIN, TENOR HERM: "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 105, no. 9, 1 May 2005 (2005-05-01), US, pages 3569 - 3576, XP055785495, ISSN: 0006-4971, DOI: 10.1182/blood-2004-07-2729
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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