Title:
APPLICATION OF POLYMERIZED HEMOGLOBIN IN PREPARATION OF DRUG FOR PREVENTING AND TREATING RESPIRATORY FAILURE
Document Type and Number:
WIPO Patent Application WO/2023/097706
Kind Code:
A1
Abstract:
Disclosed is an application of polymerized hemoglobin in the preparation of a drug for preventing and treating respiratory failure. The drug is an oxygen-carrying drug and is also a colloidal solution. The polymerized hemoglobin has the characteristics of excellent rheological properties, a long circulating residence time, normal physiological metabolic pathway, etc. Compared with whole blood or red blood cells with an oxygen-carrying function, the polymerized hemoglobin has the advantages of no requirement for matching, a working temperature range of 2-40°C, no blood coagulation risk, and a stability duration of 36 months, etc. The particle size of the polymerized hemoglobin is only one-thousandth of red blood cells, but the oxygen-carrying capacity is 7-9 times that of the red blood cells. Small-dose perfusion can relieve the tissue ischemia condition and relieve the inflammatory response, and can reach the unavailable microcirculation tail end of red blood cells for effective oxygen supply. A neuroprotective agent can also be added to prepare a complex drug, thereby further alleviating the inflammation state of a patient suffering from respiratory failure and reducing the damage of the oxygen free radical.
Inventors:
YOU KEWEI (CN)
LI JIANBO (CN)
ZHANG YANPENG (CN)
SHI SONG (CN)
WANG WENGANG (CN)
LI JIANBO (CN)
ZHANG YANPENG (CN)
SHI SONG (CN)
WANG WENGANG (CN)
Application Number:
PCT/CN2021/135696
Publication Date:
June 08, 2023
Filing Date:
December 06, 2021
Export Citation:
Assignee:
REDPHARM BEIJING BIOPHARMACEUTICAL INST CO LTD (CN)
REDPHARM BEIJING BIOTECHNOLOGY CO LTD (CN)
YOU KEWEI (CN)
REDPHARM BEIJING BIOTECHNOLOGY CO LTD (CN)
YOU KEWEI (CN)
International Classes:
A61K38/42; A61K31/4152; A61K31/7068; A61P11/06
Domestic Patent References:
| WO2016022554A1 | 2016-02-11 |
Foreign References:
| US20150064275A1 | 2015-03-05 | |||
| US20070265195A1 | 2007-11-15 | |||
| CN110563836A | 2019-12-13 |
Other References:
LANZKRON SOPHIE, MOLITERNO ALISON R., NORRIS EDWARD J., GOULD STEVEN A., SEGAL JODI, NUERMBERGER ERIC L., NESS PAUL M.: "Polymerized human Hb use in acute chest syndrome: a case report", TRANSFUSION, AMERICAN ASSOCIATION OF BLOOD BANKS, BETHESDA, MD., US, vol. 42, no. 11, 1 November 2002 (2002-11-01), US , pages 1422 - 1427, XP093070151, ISSN: 0041-1132, DOI: 10.1046/j.1537-2995.2002.00184.x
KANG YANG, ZHAO HUIMIN: "Research target and progress in hemoglobin-based oxygen carriers", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH JUNE, vol. 24, no. 20, 1 January 2020 (2020-01-01), pages 3263 - 3268, XP093070153, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2463
KANG YANG, ZHAO HUIMIN: "Research target and progress in hemoglobin-based oxygen carriers", CHINESE JOURNAL OF TISSUE ENGINEERING RESEARCH JUNE, vol. 24, no. 20, 1 January 2020 (2020-01-01), pages 3263 - 3268, XP093070153, ISSN: 2095-4344, DOI: 10.3969/j.issn.2095-4344.2463
Attorney, Agent or Firm:
BEIJING CIPRUN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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