APPLICATION OF RHCG GENE IN PREPARATION OF DRUG FOR TREATING CANCER AND DIAGNOSTIC KIT

WIPO Patent Application WO/2019/174110

A1

Disclosed in the present invention is an application of an RHCG gene in the preparation of a diagnostic kit and a targeted therapy drug for a cancer. By means of tissue level detection and immunohistochemistry, the present invention indicates that the expression of RHCG in the gastric cancer tissue is increased, and the prognosis of patients with high RHCG expression is poor; by means an in vitro cell function experiment, the present invention indicates that the gene expression of the RHCG in HGC27 and AGS cells transfected with RHCG-sgRNA is obviously reduced, the cell proliferation capacity is lowered, the gene expression of the RHCG in MKN45 and SNU719 cells transfected with Flag-RHCG is obviously increased, and the cell proliferation capacity is improved; the present invention indicates that the chemotherapy sensitivity of gastric cancer cells, of which RHCG is knocked out, to oxaliplatin is improved, and the chemotherapy sensitivity of the gastric cancer cells, in which RHCG is overexpressed, to the oxaliplatin is lowered; the RHCG is favorably applied to the preparation of a cancer diagnostic kit and a targeted cancer therapy drug.

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HUANG JIANFEI (CN)
LIU CAN (CN)
WANG YINGJING (CN)

PCT/CN2018/084505

September 19, 2019

June 07, 2018

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AFFILIATED HOSPITAL OF NANTONG UNIV (CN)

C12Q1/68; A61K31/7088; A61P35/00; C12N15/113

CN107723368A

2018-02-23

LI, SHUPING ET AL.: "Expression of Renal Ammonia Transporters Rhbg and Rhcg in Rats Fed with Low-protein Diet", CHINESE REMEDIES & CLINICS, vol. 13, no. 9, 30 September 2013 (2013-09-30), pages 1144 - 1146
GUAN, . KELEI ET AL.: "NH4C1 LO2 RHCG AQP8 (Effect of Ammonium Chloride on Gene Expression of RHCG and AQP8 in L02 Cells", BASIC & CLINICAL MEDICINE, vol. 33, no. 11, 30 November 2013 (2013-11-30), pages 1484 - 1488

KEYCOM PARTNERS, P.C. (CN)

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