Title:
APPLICATION OF A-SCAN ULTRASOUND IN DEVELOPMENT OF MYOPIA-RELATED DRUG
Document Type and Number:
WIPO Patent Application WO/2022/083034
Kind Code:
A1
Abstract:
Disclosed is a method for verifying a relaxation effect of a muscarinic receptor antagonist on a ciliary smooth muscle by measuring a change in the thickness of the lens of a non-human primate (monkey) using an A-scan ultrasound technique. The method can be used to measure effects of different concentrations of a drug under test on lens thickness, understand a dose-efficacy relationship between the drug under test and lens thickness, infer an effect of the drug on refractive accommodation, measure an effective dose, and quickly and effectively guide preclinical development of new drugs for the prevention and treatment of juvenile myopia. The method of the present invention is simple and technically stable, and has good repeatability, and does not cause tissue trauma in animals or damage to whole-body health. Experimental data obtained from monkeys (animals most similar to humans) has significant value for guiding clinical trials compared to other animals, thereby providing important translational medical information for the development of innovative drugs.
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Inventors:
LI HEPING (CN)
LIAO QIN (CN)
CAI KEYANG (CN)
LIAO QIN (CN)
CAI KEYANG (CN)
Application Number:
PCT/CN2021/075512
Publication Date:
April 28, 2022
Filing Date:
February 05, 2021
Export Citation:
Assignee:
JOINN LABORATORIES SUZHOU INC (CN)
International Classes:
A61B8/10; A61K49/00
Foreign References:
| CN112245595A | 2021-01-22 | |||
| US20120015035A1 | 2012-01-19 |
Other References:
WU, YANNING: "Observation on 1% Atropine Gel Effectiveness in Treating Myopia in Adolescents", CHINESE JOURNAL OF ETHNOMEDICINE AND ETHNOPHARMACY, no. 21, 15 November 2011 (2011-11-15), pages 71, XP055924292
BHATIA JAGDISH: "Oman Medical Specialty Board Effect of Tropicamide and Homatropine Eye Drops on A-Scan Parameters of the Phakic Normal Eyes", OMAN MEDICAL JOURNAL, vol. 26, no. 1, 1 January 2011 (2011-01-01), pages 23 - 25, XP055924293, DOI: 10. 5001/omj.2011.06
WHATHAM ANDREW R, LUNN DANIEL, JUDGE STUART J, STUART CORRESPONDENCE :, JUDGE J: "Anatomy and Pathology/Oncology Effects of Monocular Atropinization on Refractive Error and Eye Growth in Infant New World Monkeys", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 60, no. 7, 1 June 2019 (2019-06-01), US , pages 2623 - 2630, XP055924295, ISSN: 1552-5783
NISHIDA, SHOZO: "Aging Eyes and Their Impact on Regulatory Functions", INTERNATIONAL JOURNAL OF GERIATRICS, vol. 4, 31 August 1991 (1991-08-31), XP055924297
BHATIA JAGDISH: "Oman Medical Specialty Board Effect of Tropicamide and Homatropine Eye Drops on A-Scan Parameters of the Phakic Normal Eyes", OMAN MEDICAL JOURNAL, vol. 26, no. 1, 1 January 2011 (2011-01-01), pages 23 - 25, XP055924293, DOI: 10. 5001/omj.2011.06
WHATHAM ANDREW R, LUNN DANIEL, JUDGE STUART J, STUART CORRESPONDENCE :, JUDGE J: "Anatomy and Pathology/Oncology Effects of Monocular Atropinization on Refractive Error and Eye Growth in Infant New World Monkeys", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 60, no. 7, 1 June 2019 (2019-06-01), US , pages 2623 - 2630, XP055924295, ISSN: 1552-5783
NISHIDA, SHOZO: "Aging Eyes and Their Impact on Regulatory Functions", INTERNATIONAL JOURNAL OF GERIATRICS, vol. 4, 31 August 1991 (1991-08-31), XP055924297
Attorney, Agent or Firm:
SUZHOU FANGLVE PATENT AGENT FIRM ( ORDINARY PARTNERSHIP ) (CN)
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