Title:
APPLICATION OF SODIUM CAPRYLATE IN PREPARATION OF DRUG FOR IMPROVING CARDIO-PULMONARY RESUSCITATION EFFECT AND MULTIPLE ORGAN DYSFUNCTION SYNDROME AFTER CARDIO-PULMONARY RESUSCITATION
Document Type and Number:
WIPO Patent Application WO/2023/065684
Kind Code:
A1
Abstract:
The present disclosure provides an application of sodium caprylate in the preparation of a drug for improving a cardio-pulmonary resuscitation effect and multiple organ dysfunction syndrome after cardio-pulmonary resuscitation, relating to the technical field of pharmaceutical preparations. The drug for improving the cardio-pulmonary resuscitation effect and the multiple organ dysfunction syndrome after the resuscitation comprises sodium caprylate administered in a pharmaceutically effective dose. In the drug, the sodium caprylate is administered in a pharmaceutically effective dose, and the sodium caprylate is used for promoting fatty acid oxidation energy supply in the process of systemic ischemia reperfusion injury caused by cardiac arrest resuscitation, such that the cardio-pulmonary resuscitation effect and the multiple organ dysfunction syndrome after the resuscitation can be effectively improved.
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Inventors:
ZHANG MAO (CN)
XU JIEFENG (CN)
XU JIEFENG (CN)
Application Number:
PCT/CN2022/097056
Publication Date:
April 27, 2023
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K31/20; A61P1/00; A61P9/00; A61P13/12; A61P25/00
Foreign References:
| CN113730388A | 2021-12-03 |
Other References:
LEI IENGLAM, TIAN SHUO, GAO WENBIN, LIU LIU, GUO YIJING, TANG PAUL, CHEN EUGENE, WANG ZHONG: "Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation", ELIFE, vol. 10, 21 December 2021 (2021-12-21), pages 1 - 22, XP093059393, DOI: 10.7554/eLife.60311
ALVES MARCO G., OLIVEIRA PAULO J., CARVALHO RUI A.: "Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender", NMR IN BIOMEDICINE, vol. 24, no. 9, 1 November 2011 (2011-11-01), GB , pages 1029 - 1037, XP093059395, ISSN: 0952-3480, DOI: 10.1002/nbm.1640
MONTESSUIT CHRISTOPHE, PAPAGEORGIOU IRÈNE, TARDY-CANTALUPI ISABELLE, ROSENBLATT-VELIN NATHALIE, LERCH RENÉ: "Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer", JOURNAL OF APPLIED PHYSIOLOGY, vol. 89, no. 1, 1 July 2000 (2000-07-01), US , pages 111 - 119, XP093059400, ISSN: 8750-7587, DOI: 10.1152/jappl.2000.89.1.111
HARMANCEY ROMAIN, VASQUEZ HERNAN G., GUTHRIE PATRICK H., TAEGTMEYER HEINRICH: "Decreased long‐chain fatty acid oxidation impairs postischemic recovery of the insulin‐resistant rat heart", THE FASEB JOURNAL, vol. 27, no. 10, 1 October 2013 (2013-10-01), US, pages 3966 - 3978, XP093059403, ISSN: 0892-6638, DOI: 10.1096/fj.13-234914
ALVES MARCO G., OLIVEIRA PAULO J., CARVALHO RUI A.: "Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender", NMR IN BIOMEDICINE, vol. 24, no. 9, 1 November 2011 (2011-11-01), GB , pages 1029 - 1037, XP093059395, ISSN: 0952-3480, DOI: 10.1002/nbm.1640
MONTESSUIT CHRISTOPHE, PAPAGEORGIOU IRÈNE, TARDY-CANTALUPI ISABELLE, ROSENBLATT-VELIN NATHALIE, LERCH RENÉ: "Postischemic recovery of heart metabolism and function: role of mitochondrial fatty acid transfer", JOURNAL OF APPLIED PHYSIOLOGY, vol. 89, no. 1, 1 July 2000 (2000-07-01), US , pages 111 - 119, XP093059400, ISSN: 8750-7587, DOI: 10.1152/jappl.2000.89.1.111
HARMANCEY ROMAIN, VASQUEZ HERNAN G., GUTHRIE PATRICK H., TAEGTMEYER HEINRICH: "Decreased long‐chain fatty acid oxidation impairs postischemic recovery of the insulin‐resistant rat heart", THE FASEB JOURNAL, vol. 27, no. 10, 1 October 2013 (2013-10-01), US, pages 3966 - 3978, XP093059403, ISSN: 0892-6638, DOI: 10.1096/fj.13-234914
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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