Title:
APPLICATION OF TFF2 PROTEIN AND IFN-κ PROTEIN COMBINATION IN TREATMENT OF A NOVEL CORONAVIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO/2021/195883
Kind Code:
A1
Abstract:
A TFF2 protein and an IFN-κ protein are combined to treat a novel coronavirus infection. A product comprises: (a) an IFN-κ protein; (b) a TFF2 protein; and (c) an optional pharmaceutically acceptable carrier. Provided are an application of an IFN-κ protein and a TFF2 protein in the preparation of a product for the treatment of a novel coronavirus infection and related diseases, and a method for using the product to treat a novel coronavirus infection and related diseases. The foregoing combination, application, and method have excellent therapeutic effects on novel coronavirus infections, and have application prospects and social benefits.
Inventors:
XU JIANQING (CN)
ZHANG XIAOYAN (CN)
FU WEIHUI (CN)
YUAN SONGHUA (CN)
HE YONGQUAN (CN)
ZHANG XIAOYAN (CN)
FU WEIHUI (CN)
YUAN SONGHUA (CN)
HE YONGQUAN (CN)
Application Number:
PCT/CN2020/082195
Publication Date:
October 07, 2021
Filing Date:
March 30, 2020
Export Citation:
Assignee:
SHANDONG RUIYING PIONEER PHARMACEUTICAL CO LTD (CN)
International Classes:
A61P31/14; A61K39/215
Domestic Patent References:
| WO2003082196A2 | 2003-10-09 |
Foreign References:
| CN105582526A | 2016-05-18 | |||
| CN1617739A | 2005-05-18 | |||
| CN103096917A | 2013-05-08 |
Other References:
NARDELLI BERNARDETTA, ZARITSKAYA LIUBOV, SEMENUK MARK, CHO YUN HEE, LAFLEUR DAVID W., SHAH DEVANSHI, ULLRICH STEPHEN, GIROLOMONI G: "Regulatory Effect of IFN-κ, A Novel Type I IFN, On Cytokine Production by Cells of the Innate Immune System", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 169, no. 9, 1 November 2002 (2002-11-01), US , pages 4822 - 4830, XP055856383, ISSN: 0022-1767, DOI: 10.4049/jimmunol.169.9.4822
CHEN YONGWU, TANG LI-QING;ZHANG SHENG-YU;WANG MENG;SHEN AI-ZONG: "Rational administration and pharmaceutical care of interferon alpha nebulization therapy in COVID-19", CHINESE JOURNAL OF HOSPITAL PHARMACY, ZHONGGUO YAO XUEHUI WUHAN FENHUI, WUHAN, CN, vol. 40, no. 6, 1 March 2020 (2020-03-01), CN , pages 632 - 635, XP055856388, ISSN: 1001-5213
WU XIAOLING: "TFF2 Regulates Lps-induced Macrophages Polarization and Inhibits Inflammation", MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S, 1 May 2017 (2017-05-01), pages 1 - 65, XP055856392
RUDICK ET AL., NEW ENGLAND JOURNAL OF MEDICINE, vol. 354, 2006, pages 911 - 923
KLEINSCHMIDT-DEMASTERS, NEW ENGLAND JOURNAL OF MEDICINE, vol. 353, 2005, pages 369 - 379
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
CHEN YONGWU, TANG LI-QING;ZHANG SHENG-YU;WANG MENG;SHEN AI-ZONG: "Rational administration and pharmaceutical care of interferon alpha nebulization therapy in COVID-19", CHINESE JOURNAL OF HOSPITAL PHARMACY, ZHONGGUO YAO XUEHUI WUHAN FENHUI, WUHAN, CN, vol. 40, no. 6, 1 March 2020 (2020-03-01), CN , pages 632 - 635, XP055856388, ISSN: 1001-5213
WU XIAOLING: "TFF2 Regulates Lps-induced Macrophages Polarization and Inhibits Inflammation", MEDICINE AND HEALTH SCIENCES, CHINESE MASTER’S, 1 May 2017 (2017-05-01), pages 1 - 65, XP055856392
RUDICK ET AL., NEW ENGLAND JOURNAL OF MEDICINE, vol. 354, 2006, pages 911 - 923
KLEINSCHMIDT-DEMASTERS, NEW ENGLAND JOURNAL OF MEDICINE, vol. 353, 2005, pages 369 - 379
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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