Title:
APPLICATIONS OF POSTSYNAPTIC NEUROTOXIN, CARDIOTOXIN, CYTOTOXIN, PHOSPHOLIPASE A2, AND CRUDE TOXIN OF ELAPIDAE SNAKES IN COMBATING VIRAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2022/001075
Kind Code:
A1
Abstract:
Viral infections are main causes of respiratory tract infections in humans and are also causes of hepatitis and AIDS. There are many types of viruses that cause respiratory tract infections, and viruses that cause hepatitis and AIDS mutate frequently; therefore, the use of a medicament allowing the spectral suppression of viruses is clinically an urgent need. A crude toxin of Elapidae snakes and main toxins thereof, namely postsynaptic neurotoxin, cardiotoxin, cytotoxin, and phospholipase A2, serve as membrane toxins (MT) of a membrane active polypeptide; they provide a broad-spectrum virus suppression effect by means of destroying the protein coats of viruses, and thus provide a special meaning and applications in treating diseases caused by virus infections.
Inventors:
SHEN ZHEJING (CN)
Application Number:
PCT/CN2021/000131
Publication Date:
January 06, 2022
Filing Date:
June 24, 2021
Export Citation:
Assignee:
SHEN ZHEJING (CN)
International Classes:
A61K38/17; A61P31/14; A61P31/16; A61P31/18; A61P31/20; C07K14/40
Foreign References:
| CN111617108A | 2020-09-04 | |||
| CN111135288A | 2020-05-12 | |||
| CN101926980A | 2010-12-29 | |||
| CN106177909A | 2016-12-07 | |||
| US20080161538A1 | 2008-07-03 |
Other References:
RIVERO J.V.R., FOF DE CASTRO, AS STIVAL, MR MAGALHÃES, JR CARMO FILHO, IAH PFRIMER: "Mechanisms of virus resistance and antiviral activity of snake venoms", JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO, BR, vol. 17, no. 4, 30 November 2011 (2011-11-30), BR , pages 387 - 393, XP055883670, ISSN: 1678-9199, DOI: 10.1590/S1678-91992011000400005
LI JIANGBING: "Research of the Mechanism of A Small Analgesic Peptide Derived from Naja Atra Neurotoxin", CHINA MASTER’S THESES FULL-TEXT DATABASE, MEDICINE & PUBLIC HEALTH, no. 1, 31 January 2018 (2018-01-31), XP055883672
DATABASE PROTEIN 1 December 2020 (2020-12-01), ANONYMOUS : "Chain A, PHOSPHOLIPASE A2", XP055883678, retrieved from NCBI Database accession no. 1POA_A
LI JIANGBING: "Research of the Mechanism of A Small Analgesic Peptide Derived from Naja Atra Neurotoxin", CHINA MASTER’S THESES FULL-TEXT DATABASE, MEDICINE & PUBLIC HEALTH, no. 1, 31 January 2018 (2018-01-31), XP055883672
DATABASE PROTEIN 1 December 2020 (2020-12-01), ANONYMOUS : "Chain A, PHOSPHOLIPASE A2", XP055883678, retrieved from NCBI Database accession no. 1POA_A
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