APPLICATIONS OF SOLUBLE PROTEIN BAFF IN B CELL IN-VITRO CULTURE AND PROLIFERATION

Title:

APPLICATIONS OF SOLUBLE PROTEIN BAFF IN B CELL IN-VITRO CULTURE AND PROLIFERATION

Document Type and Number:

WIPO Patent Application WO/2018/032619

Kind Code:

A1

Abstract:

Disclosed in the present invention are applications of soluble protein BAFF in B cell in-vitro culture and proliferation. Peptide expressed by secretory BAFF peptide in the present invention can be effectively secreted out of cells to generate corresponding bioactivity. A cell line in the present invention can continuously secrete water-soluble BAFF protein having bioactivity in the process of culture, the water-soluble BAFF protein serving as tool cells and B cells are co-cultured, and in-vitro proliferation and antigen presentation effects of human B cells can be effectively improved.

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Inventors:

ZHANG HUI (CN)
ZHANG YIWEN (CN)
GAO SHILIN (CN)

Application Number:

PCT/CN2016/104807

Publication Date:

February 22, 2018

Filing Date:

November 07, 2016

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Assignee:

UNIV SUN YAT SEN (CN)

International Classes:

C07K19/00; C12N5/0781; C12N15/85

Foreign References:

CN101132813A	2008-02-27
CN1302305A	2001-07-04
CN103946236A	2014-07-23
CN101851278A	2010-10-06

Attorney, Agent or Firm:

JIAQUAN IP LAW FIRM (CN)

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