Title:
APPROPRIATE OSMOTIC PRESSURE RANGE OF SOLUTION CONTAINING DRUG EFFECTIVE IN LYMPHATIC DRUG DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2019/045005
Kind Code:
A1
Abstract:
Provided is an optimum formulation for intralymphatic administration containing a drug such as a pharmaceutical, cell, or nucleic acid to be used in a lymphatic drug delivery system. A drug-containing liquid formulation for delivering the drug to a target lymph node by a lymphatic drug delivery system, wherein the formulation for intralymphatic administration has an osmotic pressure of the liquid of 700-2700 kPa.
Inventors:
KODAMA TETSUYA (JP)
MORI SHIRO (JP)
MORI SHIRO (JP)
Application Number:
PCT/JP2018/032220
Publication Date:
March 07, 2019
Filing Date:
August 30, 2018
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K47/26; A61K9/08; A61K31/282; A61K31/505; A61K31/519; A61K31/704; A61K31/7088; A61K33/243; A61K35/12; A61K45/00; A61P35/00; A61P35/04
Foreign References:
| JP2015192670A | 2015-11-05 |
Other References:
HONOKA FUJII ET AL : "2B42 Development of a treatment for metastatic lymph nodes via lymphatic network", PROCEEDINGS OF THE 29TH LECTURE CONFERENCE OF BIOENGINEERING / THE PROCEEDINGS OF THE BIOENGINEERING CONFERENCE ANNUAL MEETING OF BED/JSME; JANUARY 19, 2017 - JANUARY 20, 2017, 18 January 2017 (2017-01-18), JAPAN, pages 1 - 2, XP009519525, ISSN: 2424-2829, DOI: 10.1299/jsmebio.2017.29.2B42
MIURA, YOSHINOBU ET AL.: "Early diagnosis of lymph node metastasis: Importance of intranodal pressures", CANCER SCIENCE, vol. 107, no. 3, 2016, pages 224 - 232, XP055577382, ISSN: 1349-7006
SHAO LMORI SYAGISHITA YOKUNO THATAKEYAMA YSATO TKODAMA T: "Lymphatic mapping of mice with systemic lymphoproliferative disorder: usefulness as an inter-lymph node metastasis model of cancer", J IMMUNOL METHODS, vol. 389, 2013, pages 69 - 78, XP028976305, DOI: 10.1016/j.jim.2013.01.004
MIKADA MSUKHBAATAR AMIURA YHORIE SSAKAMOTO MMORI SKODAMA T: "Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis", CANCER SCI, vol. 108, 2017, pages 846 - 852
KODAMA THATAKEYAMA YKATO SMORI S: "Visualization of fluid drainage pathways in lymphatic vessels and lymph nodes using a mouse model to test a lymphatic drug delivery system", BIOMED OPT EXPRESS, vol. 6, 2015, pages 124 - 34
KODAMA TMATSUKI DTADA ATAKEDA KMORI S: "New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network", SCI REP, vol. 6, 2016, pages 32506
"Science Data, National Astronomical Observatory", 1997, MARUZEN CO., LTD.
LI LMORI SSAKAMOTO MTAKAHASHI SKODAMA T: "Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities", PLOS ONE, vol. 8, 2013, pages e55797
SHAO LMORI SYAGISHITA YOKUNO THATAKEYAMA YSATO TKODAMA T: "Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer", J IMMUNOL METHODS, vol. 389, 2013, pages 69 - 78, XP028976305, DOI: 10.1016/j.jim.2013.01.004
See also references of EP 3677283A4
MIURA, YOSHINOBU ET AL.: "Early diagnosis of lymph node metastasis: Importance of intranodal pressures", CANCER SCIENCE, vol. 107, no. 3, 2016, pages 224 - 232, XP055577382, ISSN: 1349-7006
SHAO LMORI SYAGISHITA YOKUNO THATAKEYAMA YSATO TKODAMA T: "Lymphatic mapping of mice with systemic lymphoproliferative disorder: usefulness as an inter-lymph node metastasis model of cancer", J IMMUNOL METHODS, vol. 389, 2013, pages 69 - 78, XP028976305, DOI: 10.1016/j.jim.2013.01.004
MIKADA MSUKHBAATAR AMIURA YHORIE SSAKAMOTO MMORI SKODAMA T: "Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis", CANCER SCI, vol. 108, 2017, pages 846 - 852
KODAMA THATAKEYAMA YKATO SMORI S: "Visualization of fluid drainage pathways in lymphatic vessels and lymph nodes using a mouse model to test a lymphatic drug delivery system", BIOMED OPT EXPRESS, vol. 6, 2015, pages 124 - 34
KODAMA TMATSUKI DTADA ATAKEDA KMORI S: "New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network", SCI REP, vol. 6, 2016, pages 32506
"Science Data, National Astronomical Observatory", 1997, MARUZEN CO., LTD.
LI LMORI SSAKAMOTO MTAKAHASHI SKODAMA T: "Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities", PLOS ONE, vol. 8, 2013, pages e55797
SHAO LMORI SYAGISHITA YOKUNO THATAKEYAMA YSATO TKODAMA T: "Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer", J IMMUNOL METHODS, vol. 389, 2013, pages 69 - 78, XP028976305, DOI: 10.1016/j.jim.2013.01.004
See also references of EP 3677283A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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