Title:
APTAMER THAT TARGETS CD206-POSITIVE CELLS, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/160374
Kind Code:
A1
Abstract:
An aptamer that targets CD206-positive cells, and an application thereof as a drug carrier, a test kit, a molecular probe, etc. The aptamer can combine with CCL18 siRNA to form an anti-tumor chimera that targets CD206-positive cells, synthesis and secretion of CCL18 cytokines can be significantly inhibited, the metastasis and invasion abilities of breast cancer cells are greatly reduced, and a new therapeutic approach is provided for advanced breast cancer. The aptamer and the chimera thereof have excellent specific targeting and affinity, and are safe and highly effective; and same can be produced at scale by means of artificial synthesis.
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Inventors:
YAO YANDAN (CN)
SONG ERWEI (CN)
ZHANG MINGXIA (CN)
SONG ERWEI (CN)
ZHANG MINGXIA (CN)
Application Number:
PCT/CN2021/075671
Publication Date:
August 04, 2022
Filing Date:
February 06, 2021
Export Citation:
Assignee:
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
C12N15/115; A61K47/54
Domestic Patent References:
| WO2014011465A2 | 2014-01-16 |
Foreign References:
| CN108559748A | 2018-09-21 |
Other References:
SMITA NAIR: "Prostate Cancer Immunotherapy by Targeting Dendritic Cells In Vivo Using Receptor-Specific Aptamer Conjugated to Prostate Stem Cell Antigen (PSCA)-Encoding RNA", U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND FORT DETRICK, MARYLAND 21702-5012, 1 August 2011 (2011-08-01), pages 1 - 10, XP055608351, Retrieved from the Internet [retrieved on 20190724]
A. GANJI, A. VARASTEH, M. SANKIAN: "Aptamers: new arrows to target dendritic cells", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 24, no. 1, 2 January 2016 (2016-01-02), GB , pages 1 - 12, XP055602946, ISSN: 1061-186X, DOI: 10.3109/1061186X.2015.1041962
KHEDRI MOSTAFA; RAFATPANAH HOUSHANG; ABNOUS KHALIL; RAMEZANI POURIA; RAMEZANI MOHAMMAD: "Cancer immunotherapyvianucleic acid aptamers", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 2, 23 October 2015 (2015-10-23), NL , pages 926 - 936, XP029323472, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.10.013
SYLVESTRE MEILYN, SAXBY CHRISTOPHER P., KACHEROVSKY NATALY, GUSTAFSON HEATHER, SALIPANTE STEPHEN J., PUN SUZIE H.: "Identification of a DNA Aptamer That Binds to Human Monocytes and Macrophages", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 8, 19 August 2020 (2020-08-19), US , pages 1899 - 1907, XP055954635, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00247
A. GANJI, A. VARASTEH, M. SANKIAN: "Aptamers: new arrows to target dendritic cells", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 24, no. 1, 2 January 2016 (2016-01-02), GB , pages 1 - 12, XP055602946, ISSN: 1061-186X, DOI: 10.3109/1061186X.2015.1041962
KHEDRI MOSTAFA; RAFATPANAH HOUSHANG; ABNOUS KHALIL; RAMEZANI POURIA; RAMEZANI MOHAMMAD: "Cancer immunotherapyvianucleic acid aptamers", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 2, 23 October 2015 (2015-10-23), NL , pages 926 - 936, XP029323472, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.10.013
SYLVESTRE MEILYN, SAXBY CHRISTOPHER P., KACHEROVSKY NATALY, GUSTAFSON HEATHER, SALIPANTE STEPHEN J., PUN SUZIE H.: "Identification of a DNA Aptamer That Binds to Human Monocytes and Macrophages", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 8, 19 August 2020 (2020-08-19), US , pages 1899 - 1907, XP055954635, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00247
Attorney, Agent or Firm:
GUANGDONG HETUO LAW FIRM (CN)
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