AQUEOUS DISPERSION COMPRISING STABLE NANOPARTICLES OF A WATER-INSOLUBLE ACTIVE AND AN EXCIPIENT LIKE MIDDLE CHAIN TRIGLYCERIDES (MCT)

Title:

AQUEOUS DISPERSION COMPRISING STABLE NANOPARTICLES OF A WATER-INSOLUBLE ACTIVE AND AN EXCIPIENT LIKE MIDDLE CHAIN TRIGLYCERIDES (MCT)

Document Type and Number:

WIPO Patent Application WO/2003/013472

Kind Code:

A1

Abstract:

A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening.

Inventors:

HEDBERG PIA MARGARETHA CECILIA (SE)
SKANTZE TOMMY URBAN (SE)
VON CORSWANT LARS CHRISTIAN (SE)
ZACKRISSON ANNA ELISABETH (SE)
LINDFORS PER LENNART (SE)
OLSSON ULF (SE)

Application Number:

PCT/GB2002/003583

Publication Date:

February 20, 2003

Filing Date:

August 01, 2002

Export Citation:

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Assignee:

ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
HEDBERG PIA MARGARETHA CECILIA (SE)
SKANTZE TOMMY URBAN (SE)
VON CORSWANT LARS CHRISTIAN (SE)
ZACKRISSON ANNA ELISABETH (SE)
LINDFORS PER LENNART (SE)
OLSSON ULF (SE)

International Classes:

A61K9/10; A61K9/51; A61K47/10; A61K47/14; A61K47/44; (IPC1-7): A61K9/10; A61K9/16

Foreign References:

US5100591A

1992-03-31

Other References:

WELIN-BERGER K ET AL: "Inhibition of Ostwald ripening in local anesthetic emulsions by using hydrophobic excipients in the disperse phase.", INTERNATIONAL JOURNAL OF PHARMACEUTICS. NETHERLANDS 10 MAY 2000, vol. 200, no. 2, 10 May 2000 (2000-05-10), pages 249 - 260, XP002225985, ISSN: 0378-5173

Attorney, Agent or Firm:

Nelson, Michael Andrew (Global Intellectual Property Mereside, Alderley Par, Macclesfield Cheshire SK10 4TG, GB)

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