Title:
ARGININE METHYLTRANSFERASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/242696
Kind Code:
A1
Abstract:
Provided are an arginine methyltransferase inhibitor and a use thereof. Specifically, provided are a compound that can be used as an I-type PRMT inhibitor, a preparation method therefor, and a use thereof in the treatment of related diseases. The structure of said compound is as represented by formula (I).
Inventors:
FU XINGNIAN (CN)
WU HAIPING (CN)
WANG MENG (CN)
MI YUAN (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
WU HAIPING (CN)
WANG MENG (CN)
MI YUAN (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
Application Number:
PCT/CN2022/093688
Publication Date:
November 24, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
CYTOSINLAB THERAPEUTICS CO LTD (CN)
International Classes:
C07C211/29; A61K31/44; A61P35/00
Domestic Patent References:
| WO2016044585A1 | 2016-03-24 |
Foreign References:
| US20080280925A1 | 2008-11-13 | |||
| US20050192286A1 | 2005-09-01 | |||
| CN112533904A | 2021-03-19 | |||
| CN110845474A | 2020-02-28 | |||
| CN108947879A | 2018-12-07 | |||
| US20040053933A1 | 2004-03-18 | |||
| US20140323537A1 | 2014-10-30 | |||
| US20170280720A1 | 2017-10-05 |
Other References:
TRAN, J.A. CHEN, C.W. JIANG, W. TUCCI, F.C. FLECK, B.A. MARINKOVIC, D. ARELLANO, M. CHEN, C.: "Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 17, no. 18, 15 September 2007 (2007-09-15), Amsterdam NL , pages 5165 - 5170, XP022206845, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.06.088
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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