Title:
AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/083177
Kind Code:
A1
Abstract:
The present invention relates to an aromatic acetylene derivative, a preparation method therefor, and a medical use of a pharmaceutical composition containing the derivative. Specifically, the present invention relates to an aromatic acetylene derivative represented by a general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and a use thereof as a therapeutic agent, particularly an LPXC inhibitor; the definitions of the substituents in the general formula (I) are the same as in the description.
Inventors:
HUANG XIANGUI (CN)
CAO QI (CN)
MENG LICHEN (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
CAO QI (CN)
MENG LICHEN (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
Application Number:
PCT/CN2023/125343
Publication Date:
April 25, 2024
Filing Date:
October 19, 2023
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D413/06; A61K31/42; A61P31/04
Domestic Patent References:
| WO2020105660A1 | 2020-05-28 | |||
| WO2023011573A1 | 2023-02-09 | |||
| WO2023011574A1 | 2023-02-09 |
Other References:
TAISHO PHARMACEUTICAL CO., LTD.: "Lead Optimization of 2-Hydroxymethyl Imidazoles as Non-Hydroxamate LpxC Inhibitors: Discovery of TP0586532", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 30, 29 December 2020 (2020-12-29), XP086443796, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2020.115964
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