AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF

Title:

AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/177067

Kind Code:

A1

Abstract:

The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.

Inventors:

SHAO NING (CN)
WANG DING (CN)
YUAN HONGBIN (CN)
KAYSER FRANK (US)

Application Number:

PCT/CN2019/076926

Publication Date:

September 10, 2020

Filing Date:

March 05, 2019

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Assignee:

BIOARDIS LLC (US)

International Classes:

C07D231/56; A61K31/416; A61K31/4162; A61P35/00; C07D231/54

Domestic Patent References:

WO2016134294A1	2016-08-25
WO2018113584A1	2018-06-28
WO2019047826A1	2019-03-14

Other References:

AMIT SHRAGA , OLSHVANG EVGENIA, DAVIDZOHN NATALIA, KHOSHKENAR PAYAM, GERMAIN NICOLAS, SHURRUSH KHRIESTO, CARVALHO SILVIA, AVRAM LI: "Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor", CELL CHEMICAL BIOLOGY, vol. 26, no. 1, 17 January 2019 (2019-01-17), pages 98 - 108, XP055731312, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.10.011

Attorney, Agent or Firm:

LIU, SHEN & ASSOCIATES (CN)

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