Title:
AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177534
Kind Code:
A1
Abstract:
The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.
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Inventors:
WANG DING (CN)
SHAO NING (CN)
YUAN HONGBIN (CN)
KAYSER FRANK (US)
SHAO NING (CN)
YUAN HONGBIN (CN)
KAYSER FRANK (US)
Application Number:
PCT/CN2020/075849
Publication Date:
September 10, 2020
Filing Date:
February 19, 2020
Export Citation:
Assignee:
BIOARDIS LLC (US)
WANG DING (CN)
WANG DING (CN)
International Classes:
C07D231/56; A61K31/415; A61K31/416; A61K31/4162; A61P35/00; C07D231/54
Domestic Patent References:
WO2015108992A1 | 2015-07-23 | |||
WO2014011900A2 | 2014-01-16 | |||
WO2016064960A1 | 2016-04-28 | |||
WO2019047826A1 | 2019-03-14 |
Foreign References:
CN107286130A | 2017-10-24 |
Other References:
AMIT SHRAGA; OLSHVANG EVGENIA; DAVIDZOHN NATALIA; KHOSHKENAR PAYAM; GERMAIN NICOLAS; SHURRUSH KHRIESTO; CARVALHO SILVIA; AVRAM LIA: "Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor", CELL CHEMICAL BIOLOGY, vol. 26, no. 1, 17 January 2019 (2019-01-17), pages 98 - 108, XP055731312, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.10.011
See also references of EP 3935048A4
See also references of EP 3935048A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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