Title:
AROMATIC FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2011/024987
Kind Code:
A1
Abstract:
Disclosed is a compound having an activity of modulating a histamine-H4 receptor.
Specifically disclosed is a compound represented by formula (I) [wherein Ra and Rb independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, or the like; X represents -O- or -S(O)p-; p represents an integer of 0 to 2; Y represents =O or =S; R1 represents a halogen atom, a substituted or unsubstituted alkyl group, or the like; n represents an integer of 0 to 4; and R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or the like], a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt.
Inventors:
TACHIBANA YUUKI (JP)
MASUDA TSUTOMU (JP)
MASUDA TSUTOMU (JP)
Application Number:
PCT/JP2010/064665
Publication Date:
March 03, 2011
Filing Date:
August 30, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
TACHIBANA YUUKI (JP)
MASUDA TSUTOMU (JP)
TACHIBANA YUUKI (JP)
MASUDA TSUTOMU (JP)
International Classes:
C07D265/36; A61K31/538; A61K31/5383; A61K31/55; A61P1/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P29/02; A61P37/06; A61P37/08; A61P43/00; C07D413/04; C07D413/14; C07D498/06
Domestic Patent References:
| WO2000063197A1 | 2000-10-26 | |||
| WO1998035949A1 | 1998-08-20 | |||
| WO2004072054A1 | 2004-08-26 | |||
| WO1999050257A1 | 1999-10-07 | |||
| WO1986005490A1 | 1986-09-25 | |||
| WO1997028167A1 | 1997-08-07 | |||
| WO2004014389A1 | 2004-02-19 |
Foreign References:
| JPH01287077A | 1989-11-17 | |||
| JPS6357579A | 1988-03-12 |
Other References:
KAJINO, MASAHIRO ET AL: "Synthesis and biological activities of new 1,4-benzothiazine derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 39, no. 11, 1991, pages 2888 - 2895
HASHIMOTO, YUICHI ET AL: "A multi-centered electrophile formed from a unique bioactive cyclic hydroxamic acid, 4-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one", TETRAHEDRON, vol. 47, no. 10-11, 1991, pages 1837 - 1860
NOFAL Z. M. ET AL: "Novel coumarin derivatives with expected biological activity", MOLECULES [ELECTRONIC PUBLICATION], vol. 5, no. 2, 2000, pages 99 - 113
HASHIMOTO, YUICHI ET AL: "A multi-centered electrophile formed from a unique bioactive cyclic hydroxamic acid, 4-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one", TETRAHEDRON, vol. 47, no. 10-11, 1991, pages 1837 - 1860
NOFAL Z. M. ET AL: "Novel coumarin derivatives with expected biological activity", MOLECULES [ELECTRONIC PUBLICATION], vol. 5, no. 2, 2000, pages 99 - 113
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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