Title:
AROMATIC HETEROCYCLIC AMINE DERIVATIVE HAVING TRPV4 INHIBITING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2015/046193
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I) (In the formula, R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclic group, etc., X is -N(R2)-, -O- or -S-, Y is =C(R3)- or =N-, Z is -N(R4)-, -O- or -S-, R2 and R4 are each independently a hydrogen atom, substituted or unsubstituted alkyl, etc., R3, R5 and R6 are each independently a hydrogen atom, halogen, hydroxy, carboxy, etc., A ring is an aromatic heterocycle, etc., R7 is a halogen, hydroxy, carboxy, etc., and a is 0, 1, 2 or 3.) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition which comprises the same.
Inventors:
YUKIMASA AKIRA (JP)
TSUNO NAOKI (JP)
FUJIU MOTOHIRO (JP)
YAMAGUCHI HIROKI (JP)
NAKAI HIROMI (JP)
UENO TATSUHIKO (JP)
ICHIHASHI YUSUKE (JP)
INOUE TAKATSUGU (JP)
SUZUKI SHINJI (JP)
TSUNO NAOKI (JP)
FUJIU MOTOHIRO (JP)
YAMAGUCHI HIROKI (JP)
NAKAI HIROMI (JP)
UENO TATSUHIKO (JP)
ICHIHASHI YUSUKE (JP)
INOUE TAKATSUGU (JP)
SUZUKI SHINJI (JP)
Application Number:
PCT/JP2014/075178
Publication Date:
April 02, 2015
Filing Date:
September 24, 2014
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D277/20; A61K31/427; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/4995; A61K31/501; A61K31/506; A61K31/5377; A61K31/538; A61K31/5386; A61K31/5395; A61K31/541; A61K31/55; A61K31/553; A61P1/04; A61P3/04; A61P3/10; A61P9/00; A61P11/06; A61P13/10; A61P17/00; A61P17/16; A61P19/08; A61P19/10; A61P25/02; A61P27/02; A61P29/00; A61P35/04; A61P37/08; A61P43/00; C07D277/42; C07D417/14; C07D451/02; C07D451/04; C07D451/06; C07D471/04; C07D471/08; C07D471/10; C07D471/18; C07D487/04; C07D487/08; C07D487/10; C07D491/08; C07D491/107; C07D491/18; C07D491/20; C07D498/08; C07D498/20; C07D513/08
Domestic Patent References:
| WO2013146754A1 | 2013-10-03 | |||
| WO2007008541A2 | 2007-01-18 |
Foreign References:
| JP2007517835A | 2007-07-05 |
Other References:
LEONE,S. ET AL.: "SAR and QSAR study on 2- aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 10, 2008, pages 5695 - 5703
DATABASE REGISTRY 29 October 2014 (2014-10-29), accession no. 217018-68-2
DATABASE REGISTRY 29 October 2014 (2014-10-29), accession no. 72981-35-4
DATABASE REGISTRY 29 October 2002 (2002-10-29), accession no. 67236-86-8
DATABASE REGISTRY 22 January 2001 (2001-01-22), accession no. 15705-88-5
DATABASE REGISTRY 2 April 2010 (2010-04-02), accession no. 215546-06-7
DATABASE REGISTRY 17 September 2009 (2009-09-17), accession no. 185305-94-5
DATABASE REGISTRY 20 October 2004 (2004-10-20), accession no. 65922-23-4
DATABASE REGISTRY 8 October 2004 (2004-10-08), accession no. 58689-17-7
DATABASE REGISTRY 8 November 2002 (2002-11-08), accession no. 71915-09-0
DATABASE REGISTRY 13 August 2002 (2002-08-13), accession no. 43747-58-8
DATABASE REGISTRY 29 October 2014 (2014-10-29), accession no. 217018-68-2
DATABASE REGISTRY 29 October 2014 (2014-10-29), accession no. 72981-35-4
DATABASE REGISTRY 29 October 2002 (2002-10-29), accession no. 67236-86-8
DATABASE REGISTRY 22 January 2001 (2001-01-22), accession no. 15705-88-5
DATABASE REGISTRY 2 April 2010 (2010-04-02), accession no. 215546-06-7
DATABASE REGISTRY 17 September 2009 (2009-09-17), accession no. 185305-94-5
DATABASE REGISTRY 20 October 2004 (2004-10-20), accession no. 65922-23-4
DATABASE REGISTRY 8 October 2004 (2004-10-08), accession no. 58689-17-7
DATABASE REGISTRY 8 November 2002 (2002-11-08), accession no. 71915-09-0
DATABASE REGISTRY 13 August 2002 (2002-08-13), accession no. 43747-58-8
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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