Title:
AROMATIC HETEROCYCLIC DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/106310
Kind Code:
A1
Abstract:
The present invention pertains to: a compound, or a pharmacologically acceptable salt thereof, having GLP-1 receptor agonist activity and offering utility as an agent for treating or preventing diseases involving GLP-1 receptors; and a pharmaceutical composition containing the compound and the pharmacologically acceptable salt. A compound or a pharmaceutically acceptable salt thereof, the compound being represented by formula (IA) (where: R1 is an optionally substituted alkyl group; R2 is a group represented by BB; X is N, etc.; L is a group represented by CC (where: R8 is a hydrogen atom, etc.; R9 is a halogen, etc.; each of Z1 and Z2 is independently N, etc.; the atom labelled a bonds to a group represented by DD; and the atom labelled b bonds to a group represented by EE); W is N, etc.; R11 is a hydrogen atom, etc.; each of R12 and R13 is independently a hydrogen atom, etc.; and each of R14 and R15 is independently a hydrogen atom, etc.).
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Inventors:
KUSANO HIROKI (JP)
MIZOTE KEISUKE (JP)
KITAMURA FUJIWARA MISATO (JP)
MIZOTE KEISUKE (JP)
KITAMURA FUJIWARA MISATO (JP)
Application Number:
PCT/JP2022/045016
Publication Date:
June 15, 2023
Filing Date:
December 07, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
A61P3/04; A61K31/4375; A61K31/454; A61K31/4545; A61K31/4725; A61P3/10; A61P43/00; C07D401/14; C07D405/14; C07D413/14; C07D471/04
Domestic Patent References:
| WO2018181847A1 | 2018-10-04 | |||
| WO2020207474A1 | 2020-10-15 | |||
| WO2022228490A1 | 2022-11-03 | |||
| WO2022219495A1 | 2022-10-20 | |||
| WO2022028572A1 | 2022-02-10 | |||
| WO2022202864A1 | 2022-09-29 |
Foreign References:
| JP2020511411A | 2020-04-16 | |||
| JP2020512387A | 2020-04-23 | |||
| JP2021521265A | 2021-08-26 |
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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