AROMATIC RING COMPOUND

WIPO Patent Application WO/2017/155050

A1

Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity. A compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and is useful as a prophylactic or therapeutic agent for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease accompanied by dementia, dementia with Lewy bodies and the like.

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OGINO MASAKI (JP)
KIMURA EIJI (JP)
SUZUKI SHINKICHI (JP)
FUJI KOUJI (JP)
OHASHI TOMOHIRO (JP)
FUSHIMI MAKOTO (JP)
MASUDA KEI (JP)
KOIKE TATSUKI (JP)
WAKABAYASHI TAKESHI (JP)
YONEMORI JINICHI (JP)
YAMADA MASAMI (JP)

PCT/JP2017/009529

September 14, 2017

March 09, 2017

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TAKEDA PHARMACEUTICALS CO (JP)

C07D213/56; A61K31/415; A61K31/4192; A61K31/427; A61K31/4406; A61K31/4439; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/28; C07D231/12; C07D249/06; C07D401/04; C07D405/12; C07D405/14; C07D413/12; C07D417/12

WO2015190564A1	2015-12-17
WO2015163485A1	2015-10-29

JP2010519254A

2010-06-03

DAVOREN, J. E. ET AL.: "Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3- Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4- (1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832):Evaluation of Efficacy and Cholinergic Side Effects", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 8 June 2016 (2016-06-08), pages 6313 - 6328, XP055422238
See also references of EP 3428150A4

TAKASHIMA, Hajime (JP)

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